ZIKV Disrupts Placental Ultrastructure and Drug Transporter Expression in Mice

Congenital Zika virus (ZIKV) infection can induce fetal brain abnormalities. Here, we investigated whether maternal ZIKV infection affects placental physiology and metabolic transport potential and impacts the fetal outcome, regardless of viral presence in the fetus at term. Low (10 PFU-ZIKV ; low Z...

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Bibliographic Details
Published in:Frontiers in immunology 2021-05, Vol.12, p.680246
Main Authors: Andrade, Cherley Borba Vieira, Monteiro, Victoria Regina de Siqueira, Coelho, Sharton Vinicius Antunes, Gomes, Hanailly Ribeiro, Sousa, Ronny Paiva Campos, Nascimento, Veronica Muller de Oliveira, Bloise, Flavia Fonseca, Matthews, Stephen Giles, Bloise, Enrrico, Arruda, Luciana Barros, Ortiga-Carvalho, Tania Maria
Format: Article
Language:English
Subjects:
ABCA1
ABCG1
Animals
Apoptosis
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - metabolism
Biomarkers
Female
Gene Expression
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Immunity
Immunocompromised Host
Immunohistochemistry
Immunology
Male
Mice
P-glycoprotein (P-gp) breast cancer resistance protein (BCRP)
placenta
Placenta - ultrastructure
Placenta - virology
Pregnancy
Pregnancy Complications, Infectious
ultrastructure
Zika Virus - physiology
Zika Virus Infection - genetics
Zika Virus Infection - pathology
Zika Virus Infection - virology
ZIKV
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Summary:Congenital Zika virus (ZIKV) infection can induce fetal brain abnormalities. Here, we investigated whether maternal ZIKV infection affects placental physiology and metabolic transport potential and impacts the fetal outcome, regardless of viral presence in the fetus at term. Low (10 PFU-ZIKV ; low ZIKV) and high (5x10 PFU-ZIKV ; high ZIKV) virus titers were injected into immunocompetent (ICompetent C57BL/6) and immunocompromised (ICompromised A129) mice at gestational day (GD) 12.5 for tissue collection at GD18.5 (term). High ZIKV elicited fetal death rates of 66% and 100%, whereas low ZIKV induced fetal death rates of 0% and 60% in C57BL/6 and A129 dams, respectively. All surviving fetuses exhibited intrauterine growth restriction (IUGR) and decreased placental efficiency. High-ZIKV infection in C57BL/6 and A129 mice resulted in virus detection in maternal spleens and placenta, but only A129 fetuses presented virus RNA in the brain. Nevertheless, pregnancies in both strains produced fetuses with decreased head sizes (p
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.680246