Multiparametric Material Functionality of Microtissue‐Based In Vitro Models as Alternatives to Animal Testing

With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific, economic, and legal point of view. Microtissue‐b...

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Bibliographic Details
Published in:Advanced science 2022-04, Vol.9 (10), p.e2105319-n/a
Main Authors: Stengelin, Elena, Thiele, Julian, Seiffert, Sebastian
Format: Article
Language:English
Subjects:
3R principle
Animal Testing Alternatives
Animal welfare
Animals
Automation
Biocompatibility
Engineering
Ethics
EU directives
Experiments
Hydrogels
in vitro models
microtissue engineering
Organisms
Reproducibility
Review
Reviews
Spheroids
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Summary:With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific, economic, and legal point of view. Microtissue‐based in vitro model systems offer a valuable approach to address this issue by accounting for the complexity of natural tissues in a simplified manner. To increase the functionality of these model systems and thus make their use as a substitute for animal testing more likely in the future, the fundamentals need to be continuously improved. Corresponding requirements exist in the development of multifunctional, hydrogel‐based materials, whose properties are considered in this review under the aspects of processability, adaptivity, biocompatibility, and stability/degradability. Overview of microtissue‐based in vitro model systems as a possible substitute for animal testing according to the 3R principle from Russel and Burch is presented herein. Special attention is given to fabrication techniques, to natural and synthetic materials, as well as to multifunctional material properties, such as processability, adaptivity, biocompatibility, and stability/degradability.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202105319