Covalent Organic Framework-Based Theranostic Platforms for Restricting H1N1 Influenza Virus Infection

• Published in: International journal of nanomedicine 2024-01, Vol.19, p.7399-7414
• Main Authors: Ding, Luo-Gang, Ji, Xiang, Liu, Yue-Yue, Shi, Min, Li, Jian-Da, Liu, Fei, Zhang, Yu-Yu, Yu, Jiang, Wu, Jia-Qiang
• Format: Article
• Language: English
• Subjects: Amides - chemistry; Amides - pharmacology; Animals; Antiviral agents; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; controlled release; crystal porous materials; diagnosis and therapy; Dogs; Drug Carriers - chemistry; Drug Liberation; Drug resistance; Fluorescence; fluorescence imaging; Health aspects; Humans; Influenza A Virus, H1N1 Subtype - drug effects; Influenza viruses; Influenza, Human - drug therapy; Madin Darby Canine Kidney Cells; Metal-Organic Frameworks - chemistry; Metal-Organic Frameworks - pharmacology; Mice; Mice, Inbred BALB C; microenvironment-responsive; Orthomyxoviridae Infections - drug therapy; Porosity; Pyrazines - chemistry; Pyrazines - pharmacokinetics; Pyrazines - pharmacology; Pyrazines - therapeutic use; RNA; Swine influenza; Theranostic Nanomedicine - methods; Vaccines; Virus diseases
• ISSN: 1178-2013; 1178-2013
• DOI: 10.2147/IJN.S461866

Influenza A (H1N1) virus is a highly contagious respiratory disease that causes severe illness and death. Vaccines and antiviral drugs are limited by viral variation and drug resistance, so developing efficient integrated theranostic options appears significant in anti-influenza virus infection. In this study, we designed and fabricated covalent organic framework (COF) based theranostic platforms (T705@DATA-COF-Pro), which was composed of an RNA polymerase inhibitor (favipiravir, T705), the carboxyl-enriched COF (DATA-COF) nano-carrier and Cy3-labeled single DNA (ssDNA) probe. The multi-porosity COF core provided an excellent micro-environment and smooth delivery for T705. The ssDNA probe coating bound to the nucleic acids of H1N1 selectively, thus controlling drug release and allowing fluorescence imaging. The combination of COF and probe triggered the synergism, promoting drug further therapeutic outcomes. With the aid of T705@DATA-COF-Pro platforms, the H1N1-infected mouse models lightly achieved diagnosis and significantly prolonged survival. This research underscores the distinctive benefits and immense potential of COF materials in nano-preparations for virus infection, offering novel avenues for the detection and treatment of H1N1 virus infection.