Influence of Gallic Acid-Containing Mouth Spray on Dental Health and Oral Microbiota of Healthy Dogs: A Pilot Study

The pilot study aimed to investigate the effects of GAMS on oral microbiota in healthy dog subjects. Thirty-eight dogs were recruited and randomly allocated to the placebo ( = 19) and treatment groups ( = 19). The dogs were treated with mouth spray once daily for 42 days. The changes in the gingival...

Full description

Saved in:
Bibliographic Details
Published in:Veterinary sciences 2023-06, Vol.10 (7), p.424
Main Authors: Thongma, Nichaphat, Sivamaruthi, Bhagavathi Sundaram, Bharathi, Muruganantham, Tansrisook, Chawin, Peerajan, Sartjin, Tanongpitchayes, Kittidaj, Chawnan, Natcha, Rashmi, Subramanian, Thongkorn, Kriangkrai, Chaiyasut, Chaiyavat
Format: Article
Language:English
Subjects:
Acids
Analysis
Anesthesia
Bacteria
Biofilms
calculus index
Dogs
Gallic acid
Gingival index
Metagenomics
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Mouth
Oral health
Oral hygiene
oral microbiome
Pathogens
Periodontal diseases
Phenols
Placebos
Plaque index
Preservatives
QIIME 2.0TM
Statistical significance
Teeth
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The pilot study aimed to investigate the effects of GAMS on oral microbiota in healthy dog subjects. Thirty-eight dogs were recruited and randomly allocated to the placebo ( = 19) and treatment groups ( = 19). The dogs were treated with mouth spray once daily for 42 days. The changes in the gingival index (GI), plaque index (PI), and calculus index (CI) were measured at baseline (day 0) and end of the study (42nd day). The changes in the oral microbial composition of representative dogs (placebo, = 7; and treatment, = 7) were also evaluated at baseline and end of the study. Oral microbial composition was assessed by sequencing. The sequences were annotated using the QIIME 2.0 . The GI, PI, and CI indexes were reduced after the GAMS usage. The abundance of the commensal bacterial phylum Actinobacteria and Chloroflexi, genera , and was improved after six weeks of GAMS usage. GAMS reduced the pathogenic bacterial species, including sp., sp., , and Moreover, some pathogenic bacterial abundances were increased at the end of the study. All the microbial variations were observed within the group. The inter-group analysis revealed that the changes were unrelated to GAMS usage. Further studies need to be carried out using more experimental subjects to confirm the effectiveness of GAMS. More metagenomic data are required to evidence the GMAS impact on the oral microbiome of healthy dogs.
ISSN:2306-7381
2306-7381
DOI:10.3390/vetsci10070424