Effects of marine-derived n–3 PUFA supplementation on soluble adhesion molecules: A systematic review and dose-response meta-analysis of randomized controlled trials

Long-chain n–3 poly unsaturated fatty acids have anti-inflammatory effects but their effects on serum levels of adhesion molecules are inconsistent and contradictory. In this updated systematic review and meta-analysis, marine sources of omega-3 fatty acids were pooled up to determine the effects of...

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Bibliographic Details
Published in:Pharmacological research 2023-11, Vol.197, p.106963-106963, Article 106963
Main Authors: Shirani, Mahsa, Talebi, Shokoofeh, Sadeghi, Omid, Hassanizadeh, Shirin, Askari, Gholamreza, Bagherniya, Mohammad, Sahebkar, Amirhossein
Format: Article
Language:English
Subjects:
Cell Adhesion Molecules
Fatty Acids
Inflammation
Meta-analysis
Omega-3
VCAM-1
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Summary:Long-chain n–3 poly unsaturated fatty acids have anti-inflammatory effects but their effects on serum levels of adhesion molecules are inconsistent and contradictory. In this updated systematic review and meta-analysis, marine sources of omega-3 fatty acids were pooled up to determine the effects of omega-3 supplementation on adhesion molecules. PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases (from inception to April 2023) were searched and all RCTs investigating the effects of marine sources of omega-3, on blood concentrations of adhesion molecules were included and a meta-analysis undertaken. Forty-two RCTs were included involving 3555 participants aged from 18 to 75 years. Meta-analysis of 38 arms from 30 RCTs reporting serum concentrations of vascular cell adhesion molecule-1 (VCAM-1) showed a significant reduction after omega-3 supplementation (WMD: −1.26, 95% CI: −1.88 to −0.64 ng/mL, P 
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2023.106963