Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis

Gastric cancer is a deadly tumor and a relatively common disease worldwide. Surgical resection and chemotherapy are the main clinical options to treat this type of disease, however the median overall survival rate is limited to one year. Thus, the development of new therapies is a highly necessary c...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-12, Vol.19 (12), p.3983
Main Authors: Andreuzzi, Eva, Capuano, Alessandra, Pellicani, Rosanna, Poletto, Evelina, Doliana, Roberto, Maiero, Stefania, Fornasarig, Mara, Magris, Raffaella, Colombatti, Alfonso, Cannizzaro, Renato, Spessotto, Paola, Mongiat, Maurizio
Format: Article
Language:English
Subjects:
Angiogenesis
Antiangiogenic agents
Antiangiogenics
Blood vessels
Cancer therapies
Chemotherapy
Clinical trials
Elastin microfibril interface located protein
endomicroscopy
Endoscopy
extracellular matrix
Gastric cancer
lymphangiogenesis
Metastasis
Mucosa
Patients
Proteins
Tumor microenvironment
Tumors
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Summary:Gastric cancer is a deadly tumor and a relatively common disease worldwide. Surgical resection and chemotherapy are the main clinical options to treat this type of disease, however the median overall survival rate is limited to one year. Thus, the development of new therapies is a highly necessary clinical need. Angiogenesis is a promising target for this tumor type, however clinical trials with the use of anti-angiogenic drugs have so far not met expectations. Therefore, it is important to better characterize the expression of molecules whose expression levels may impact on the efficacy of the treatments. In this study the characteristics of the gastric tumor associated blood vessels were first assessed by endomicroscopy. Next, we analyzed the expression of Multimerin-2, EMILIN-2 and EMILIN-1, three molecules of the EMI Domain ENdowed (EDEN) protein family. These molecules play important functions in the tumor microenvironment, affecting cancer progression both directly and indirectly impinging on angiogenesis and lymphangiogenesis. All the molecules were highly expressed in the normal mucosa whereas in a number of patients their expression was altered. We consider that better characterizing the gastric tumor microenvironment and the quality of the vasculature may achieve effective patient tailored therapies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19123983