Prognostic significance of combined pretreatment body mass index (BMI) and BMI loss in patients with esophageal cancer

Body mass index (BMI) has been associated with a risk of esophageal cancer. However, the influence of BMI and BMI loss on people with esophageal cancer that were treated with different therapies has not been described in China. In total, 615 consecutive patients that underwent esophagectomy and/or c...

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Bibliographic Details
Published in:Cancer management and research 2019-01, Vol.11, p.3029-3041
Main Authors: Gu, Wen-Shen, Fang, Wei-Zhen, Liu, Chun-Yue, Pan, Kun-Yi, Ding, Rui, Li, Xiao-Hui, Duan, Chao-Hui
Format: Article
Language:English
Subjects:
Analysis
Asia
BMI
BMI loss
Body mass index
Cancer patients
Cancer therapies
Carcinoma
Care and treatment
Chemotherapy
China
Esophageal cancer
Health aspects
Hypertension
long-term survival
Mortality
Obesity
Operating systems (Software)
Original Research
Radiation therapy
Radiotherapy
Squamous cell carcinoma
Surgery
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Summary:Body mass index (BMI) has been associated with a risk of esophageal cancer. However, the influence of BMI and BMI loss on people with esophageal cancer that were treated with different therapies has not been described in China. In total, 615 consecutive patients that underwent esophagectomy and/or chemotherapy/radiotherapy were classified according to the Asian-specific BMI (kg/m ) cutoff values. The impact of BMI and BMI loss on long-term overall survival (OS) was estimated using the Kaplan-Meier method and Cox proportional hazard models. Multivariate analysis showed that overweight and obese patients had a more favorable survival than normal weight and underweight patients ( =0.017). Patients with a low BMI and high BMI loss before therapy had worse OS than others ( =0.001). Subgroup analysis showed that patients with a high BMI were more likely to suffer hypertension (
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S197820