Systemic infection caused by the methicillin-resistant Staphylococcus aureus USA300-LV lineage in a Brazilian child previously colonized

The methicillin-resistant Staphylococcus aureus (MRSA) USA300-Latin American variant (USA300-LV) lineage is well documented in northern Latin American countries. It has replaced established clones in hospital environments. We herein report a systemic infection caused by a USA300-LV isolate in a 15-y...

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Published in:The Brazilian journal of infectious diseases 2023-03, Vol.27 (2), p.102737, Article 102737
Main Authors: Whitaker, Carolina de Oliveira, Chamon, Raiane Cardoso, de Oliveira, Tamara Lopes Rocha, Nouér, Simone Aranha, dos Santos, Kátia Regina Netto
Format: Article
Language:English
Subjects:
Adolescent
Brazil
Case Report
Case studies
Causes of
Child
Communicable diseases in children
Community-acquired infections
Community-Acquired Infections - epidemiology
Humans
Infection
INFECTIOUS DISEASES
Male
Methicillin-Resistant Staphylococcus aureus - genetics
MRSA
Nasal colonization
Sepsis
Staphylococcal Infections - diagnosis
Staphylococcal Infections - epidemiology
Staphylococcus aureus infections
United States
USA300-LV
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Summary:The methicillin-resistant Staphylococcus aureus (MRSA) USA300-Latin American variant (USA300-LV) lineage is well documented in northern Latin American countries. It has replaced established clones in hospital environments. We herein report a systemic infection caused by a USA300-LV isolate in a 15-year-old boy, from a low-income area of Rio de Janeiro, previously colonized by the same strain. During hospital stay, seven pvl-positive MRSA USA300-LV isolates were recovered by nasal swab, blood and abscess secretion. The patient underwent intravenous vancomycin, daptomycin, and oral sulfamethoxazole/trimethoprim, and was discharged after 45 days after full recovery. This is the first documented case of a community-acquired MRSA infection caused by the USA300-LV variant in Brazil in a previously colonized adolescent with no history of recent travel outside of Rio de Janeiro. The need for improved surveillance programs to detect MRSA colonization in order to control the spread of hypervirulent lineages among community and hospital settings is highlighted.
ISSN:1413-8670
1678-4391
1678-4391
DOI:10.1016/j.bjid.2022.102737