Identification and characterization of long noncoding RNAs and mRNAs expression profiles related to postnatal liver maturation of breeder roosters using Ribo-zero RNA sequencing

The liver is mainly hematopoietic in the embryo, and converts into a major metabolic organ in the adult. Therefore, it is intensively remodeled after birth to adapt and perform adult functions. Long non-coding RNAs (lncRNAs) are involved in organ development and cell differentiation, likely they hav...

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Bibliographic Details
Published in:BMC genomics 2018-06, Vol.19 (1), p.498-498, Article 498
Main Authors: Wu, Shengru, Liu, Yanli, Guo, Wei, Cheng, Xi, Ren, Xiaochun, Chen, Si, Li, Xueyuan, Duan, Yongle, Sun, Qingzhu, Yang, Xiaojun
Format: Article
Language:English
Subjects:
Analysis
Animals
Apoptosis
Bioinformatics
Biological activity
Cell cycle
Cell differentiation
Cell proliferation
Chicken
Chickens
Differential expression
Differentiation (biology)
DNA methylation
Exons
Gallus gallus
Gene expression
Gene Expression Profiling - methods
Gene sequencing
Genes
Genomes
Genomics
Hedgehog protein
Hepatocytes
Hepatology
Liver
Liver - metabolism
LncRNAs
Male
Maturation
Messenger RNA
Metabolism
Molecular genetics
Notch protein
Postnatal liver maturation
Poultry
Proteins
Ribonucleic acid
RNA
RNA sequencing
RNA, Long Noncoding - genetics
RNA, Messenger - genetics
Sequence Analysis, RNA - methods
Signal transduction
Signaling
Transcription
Transcription (Genetics)
Transcriptome
Wnt protein
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Summary:The liver is mainly hematopoietic in the embryo, and converts into a major metabolic organ in the adult. Therefore, it is intensively remodeled after birth to adapt and perform adult functions. Long non-coding RNAs (lncRNAs) are involved in organ development and cell differentiation, likely they have potential roles in regulating postnatal liver development. Herein, in order to understand the roles of lncRNAs in postnatal liver maturation, we analyzed the lncRNAs and mRNAs expression profiles in immature and mature livers from one-day-old and adult (40 weeks of age) breeder roosters by Ribo-Zero RNA-Sequencing. Around 21,939 protein-coding genes and 2220 predicted lncRNAs were expressed in livers of breeder roosters. Compared to protein-coding genes, the identified chicken lncRNAs shared fewer exons, shorter transcript length, and significantly lower expression levels. Notably, in comparison between the livers of newborn and adult breeder roosters, a total of 1570 mRNAs and 214 lncRNAs were differentially expressed with the criteria of log fold change > 1 or 
ISSN:1471-2164
1471-2164
DOI:10.1186/s12864-018-4891-7