Changes in Serotonin Modulation of Glutamate Currents in Pyramidal Offspring Cells of Rats Treated With 5-MT during Gestation

Changes in stimuli and feeding in pregnant mothers alter the behavior of offspring. Since behavior is mediated by brain activity, it is expected that postnatal changes occur at the level of currents, receptors or soma and dendrites structure and modulation. In this work, we explore at the mechanism...

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Bibliographic Details
Published in:Brain sciences 2020-04, Vol.10 (4), p.221
Main Authors: Hernández-Carballo, Gustavo, Ruíz-Luna, Evelyn A, López-López, Gustavo, Manjarrez, Elias, Flores-Hernández, Jorge
Format: Article
Language:English
Subjects:
5-HT
Acids
Autism
Behavior
Brain
Dendrites
development
Gestation
Glutamic acid receptors
hyperserotonemia
Hypotheses
Mental disorders
N-Methyl-D-aspartic acid
neurodevelopment
Neuromodulation
neurotransmitters
Offspring
Prefrontal cortex
Pregnancy
Pyramidal cells
Serotonin
Studies
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Summary:Changes in stimuli and feeding in pregnant mothers alter the behavior of offspring. Since behavior is mediated by brain activity, it is expected that postnatal changes occur at the level of currents, receptors or soma and dendrites structure and modulation. In this work, we explore at the mechanism level the effects on Sprague-Dawley rat offspring following the administration of serotonin (5-HT) agonist 5-methoxytryptamine (5-MT). We analyzed whether 5-HT affects the glutamate-activated (I ) and N-methyl-D-aspartate (NMDA)-activated currents (I , I ) in dissociated pyramidal neurons from the prefrontal cortex (PFC). For this purpose, we performed voltage-clamp experiments on pyramidal neurons from layers V-VI of the PFC of 40-day-old offspring born from 5-MT-treated mothers at the gestational days (GD) 11 to 21. We found that the pyramidal-neurons from the PFC of offspring of mothers treated with 5-MT exhibit a significant increased reduction in both the I and I when 5-HT was administered. Our results suggest that the concentration increase of a neuromodulator during the gestation induces changes in its modulatory action over the offspring ionic currents during the adulthood thus contributing to possible psychiatric disorders.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci10040221