Quantitative measurement of macromolecular tissue properties in white and gray matter in healthy aging and amnestic MCI

Healthy and pathological aging influence brain microstructure via complex processes. Discerning these processes requires measurements that are sensitive to specific biological properties of brain tissue. We integrated a novel quantitative R1 measure with multi-shell diffusion weighted imaging to map...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2021-08, Vol.237, p.118161-118161, Article 118161
Main Authors: Gozdas, Elveda, Fingerhut, Hannah, Wu, Hua, Bruno, Jennifer L., Dacorro, Lauren, Jo, Booil, O'Hara, Ruth, Reiss, Allan L., Hosseini, S.M. Hadi
Format: Article
Language:English
Subjects:
Activities of daily living
Age
Aging
Alzheimer's disease
Biomarkers
Brain research
Cognition & reasoning
Cognitive ability
Dementia
Diffusion
Healthy aging
Macromolecular
Macromolecules
Magnetic resonance imaging
Medical imaging
Memory
Mild Cognitive Impairment
Neurodegeneration
Neuroimaging
Quantitative MRI
Substantia alba
Substantia grisea
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Summary:Healthy and pathological aging influence brain microstructure via complex processes. Discerning these processes requires measurements that are sensitive to specific biological properties of brain tissue. We integrated a novel quantitative R1 measure with multi-shell diffusion weighted imaging to map age-associated changes in macromolecular tissue volume (MTV) along major white matter tracts in healthy older adults and patients with amnestic Mild Cognitive Impairment (aMCI). Reduced MTV in association tracts was associated with older age in healthy aging, was correlated with memory performance, and distinguished aMCI from controls. We also mapped changes in gray matter tissue properties using quantitative R1 measurements. We documented a widespread decrease in R1 with advancing age across the cortex and decreased R1 in aMCI compared with controls in regions implicated in episodic memory. Our data are the first to characterize MTV loss along major white matter tracts in aMCI and suggest that qMRI is a sensitive measure for detecting subtle degeneration of white and gray matter tissue that cannot be detected by conventional MRI and diffusion measures.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2021.118161