Link Between Elevated Long-Term Resting Heart Rate Variability and Pulse Pressure Variability for All-Cause Mortality

Background Elevated long-term systolic blood pressure and resting heart rate (RHR) variability are suggested to amplify the risk of all-cause mortality (ACM). However, the link between increased RHR and pulse pressure for ACM remained unclear. Methods and Results This study analyzed 46 751 individua...

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Bibliographic Details
Published in:Journal of the American Heart Association 2020-03, Vol.9 (6), p.e014122-e014122
Main Authors: Yang, Xiaolei, Hidru, Tesfaldet Habtemariam, Han, Xu, Zhang, Xinyuan, Liu, Yang, Wang, Binhao, Li, Huihua, Wu, Shouling, Xia, Yun-Long
Format: Article
Language:English
Subjects:
Adult
Aged
all‐cause death
Blood Pressure
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - mortality
Cardiovascular Diseases - physiopathology
Cause of Death
China
Female
Heart Rate
Humans
Hypertension - mortality
Hypertension - physiopathology
Male
Middle Aged
Original Research
Prospective Studies
pulse pressure
Risk Assessment
Risk Factors
Time Factors
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Summary:Background Elevated long-term systolic blood pressure and resting heart rate (RHR) variability are suggested to amplify the risk of all-cause mortality (ACM). However, the link between increased RHR and pulse pressure for ACM remained unclear. Methods and Results This study analyzed 46 751 individuals from Kailuan Cohort Study for the end outcome of ACM. A Cox regression model was used to estimate hazard ratios for death events. Kaplan-Meier analysis was performed to study the differences in survival as stratified by the SD, coefficient of variation, and average real variability of RHR and pulse pressure quartiles. A total of 1667 deaths (65 years of age had a higher risk for ACM across quartiles of RHR-SD. The hazard ratio (95% CI) for the subjects in quartiles 2, 3, and 4 were 1.81 (1.10-2.97), 2.31 (1.37-1.3.90), and 2.64 (1.63-4.29), respectively. Conclusions An elevated long-term RHR variability combined with an increased pulse pressure variability or vice versa amplifies the risk of ACM.
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.119.014122