Stereoselective Synthesis of the C19–C39 Fragment of Bastimolide A

Abstract This paper describes the synthesis of the C19–C39 fragment of the antimalarial natural product bastimolide A via addition of a functionalized C19–C26 alkyne fragment to a C27–C39 aldehyde fragment. Opening of a terminal epoxide and Noyori asymmetric reduction were used as key steps in the s...

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Bibliographic Details
Published in:SynOpen (2017) 2021-10, Vol.5 (4), p.285-290
Main Authors: Kumar, Nemilikonda Sravan, Ramulu, B. Janaki, Ghosh, Subhash
Format: Article
Language:English
Subjects:
antimalarial activity
bastimolide a
epoxide opening
noyori asymmetric reduction
stereoselective synthesis
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Summary:Abstract This paper describes the synthesis of the C19–C39 fragment of the antimalarial natural product bastimolide A via addition of a functionalized C19–C26 alkyne fragment to a C27–C39 aldehyde fragment. Opening of a terminal epoxide and Noyori asymmetric reduction were used as key steps in the synthesis.
ISSN:2509-9396
2509-9396
DOI:10.1055/a-1647-7202