SARS-CoV-2 Infection of Unvaccinated Liver- and Kidney-Transplant Recipients: A Single-Center Experience of 103 Consecutive Cases

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was declared a pandemic in March 2020. Its reported impact on solid-organ-transplant-recipient morbidity and mortality has varied. The aim of this study was to present the effect of transplant status, patient comorbidities and immunosuppre...

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Published in:Transplantology (Basel, Switzerland) Switzerland), 2022-06, Vol.3 (2), p.200-207
Main Authors: Hardgrave, Hailey, Wells, Allison, Nigh, Joseph, Osborn, Tamara, Klutts, Garrett, Krinock, Derek, Rude, Mary Katherine, Bhusal, Sushma, Burdine, Lyle, Giorgakis, Emmanouil
Format: Article
Language:English
Subjects:
Age groups
Coronaviruses
COVID-19
Diabetes
Fatalities
Hypertension
immunosuppression
Infections
Liver
Mortality
Pandemics
Patients
Population
Severe acute respiratory syndrome coronavirus 2
solid-organ transplant
Transplants & implants
unvaccinated
Viral infections
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Summary:Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was declared a pandemic in March 2020. Its reported impact on solid-organ-transplant-recipient morbidity and mortality has varied. The aim of this study was to present the effect of transplant status, patient comorbidities and immunosuppression modality on the survival of solid-organ-transplant recipients who contracted SAR-CoV-2 during the pre-vaccination era, at a single academic transplant center. Patients (n = 103) were assessed for 90-day mortality. A univariate analysis identified an age of over 60 years (HR = 10, p = 0.0034), Belatacept (HR = 6.1, p = 0.022), and Cyclosporine (HR = 6.1, p = 0.0089) as significant mortality risk factors; Tacrolimus was protective (HR = 0.23, p = 0.022). Common metabolic comorbidities (hypertension, diabetes, obesity) did not stand out as risk factors in our patient cohort. This study on the unvaccinated is expected to facilitate a paired comparison of outcomes in transplanted patients who contracted SARS-CoV-2 during the latter period of the pandemic, when broad SARS-CoV-2 vaccination and novel antibody treatments became broadly available.
ISSN:2673-3943
2673-3943
DOI:10.3390/transplantology3020021