Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside

Phospholipases are essential intermediaries that work as hydrolyzing enzymes of phospholipids (PLs), which represent the most abundant species contributing to the biological membranes of nervous cells of the healthy human brain. They generate different lipid mediators, such as diacylglycerol, phosph...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-05, Vol.13 (5), p.798
Main Authors: Marvi, Maria Vittoria, Neri, Irene, Evangelisti, Camilla, Ramazzotti, Giulia, Asioli, Sofia, Zoli, Matteo, Mazzatenta, Diego, Neri, Niccolò, Morandi, Luca, Tonon, Caterina, Lodi, Raffaele, Franceschi, Enrico, McCubrey, James A, Suh, Pann-Ghill, Manzoli, Lucia, Ratti, Stefano
Format: Article
Language:English
Subjects:
Acids
Arachidonic acid
Brain - metabolism
Brain cancer
Brain Neoplasms - therapy
Brain tumors
Care and treatment
Cell migration
Cell proliferation
Cyclin-dependent kinases
Development and progression
Diglycerides
Enzymes
Epidermal growth factor
Glioma
Glioma - therapy
Gliomas
Health aspects
Humans
Kinases
Lipids
Localization
Lysophosphatidic acid
Membranes
Phosphatidic acid
Phospholipases
Phospholipases - metabolism
Phospholipids
Physiology
prognostic biomarker
Proteins
Review
Roles
therapeutic target
Therapeutic targets
Tumors
Citations: Items that this one cites
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Summary:Phospholipases are essential intermediaries that work as hydrolyzing enzymes of phospholipids (PLs), which represent the most abundant species contributing to the biological membranes of nervous cells of the healthy human brain. They generate different lipid mediators, such as diacylglycerol, phosphatidic acid, lysophosphatidic acid, and arachidonic acid, representing key elements of intra- and inter-cellular signaling and being involved in the regulation of several cellular mechanisms that can promote tumor progression and aggressiveness. In this review, it is summarized the current knowledge about the role of phospholipases in brain tumor progression, focusing on low- and high-grade gliomas, representing promising prognostic or therapeutic targets in cancer therapies due to their influential roles in cell proliferation, migration, growth, and survival. A deeper understanding of the phospholipases-related signaling pathways could be necessary to pave the way for new targeted therapeutic strategies.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13050798