A double-edged sword: ROS related therapies in the treatment of psoriasis

In the onset and progression of psoriasis, redox imbalance is a vital factor. It's widely accepted that too much reactive oxygen species (ROS) always make psoriasis worse. Recent research, however, has shown that the accumulation of ROS is not entirely detrimental, as it helps reduce psoriasis...

Full description

Saved in:
Bibliographic Details
Published in:Asian journal of pharmceutical sciences 2022-11, Vol.17 (6), p.798-816
Main Authors: Hu, Jingyi, Bian, Qiong, Ma, Xiaolu, Xu, Yihua, Gao, Jianqing
Format: Article
Language:English
Subjects:
Antioxidant
Psoriasis
Review
ROS accumulation
ROS related therapies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the onset and progression of psoriasis, redox imbalance is a vital factor. It's widely accepted that too much reactive oxygen species (ROS) always make psoriasis worse. Recent research, however, has shown that the accumulation of ROS is not entirely detrimental, as it helps reduce psoriasis lesions by inhibiting epidermal proliferation and keratinocyte death. As a result, ROS appears to have two opposing effects on the treatment of psoriasis. In this review, the current ROS-related therapies for psoriasis, including basic and clinical research, are presented. Additionally, the design and therapeutic benefits of various drug delivery systems and therapeutic approaches are examined, and a potential balance between anti-oxidative stress and ROS accumulation is also trying to be investigated. ROS plays a double-edged role in the treatment of psoriasis. Reducing the level of ROS can alleviate oxidative stress, while the accumulation of ROS inhibits epidermal hyperplasia by inducing apoptosis. Both ways can improve the symptoms of psoriasis. [Display omitted]
ISSN:1818-0876
2221-285X
DOI:10.1016/j.ajps.2022.10.005