Response to letter regarding “Clinical features, diagnosis, and survival analysis of dogs with glioma”

• Published in: Journal of veterinary internal medicine 2022-09, Vol.36 (5), p.1568-1569
• Main Authors: José‐López, Roberto, Gutierrez‐Quintana, Rodrigo, Pumarola, Martí, Fuente, Cristian, Añor, Sonia, Manzanilla, Edgar G., Suñol, Anna, Pi Castro, Dolors, Sánchez‐Masian, Daniel, Fernández‐Flores, Francisco, Marioni‐Henry, Katia, Matiasek, Lara A., Matiasek, Kaspar, Ricci, Emanuele
• Format: Article
• Language: English
• Subjects: Animal euthanasia; Brain cancer; Chemotherapy; Medical prognosis; Radiation therapy; Statistical analysis; Surgery; Survival analysis; Tumors
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/jvim.16488

[...]liberally comparing outcomes and survival after radiotherapy in dogs with unconfirmed glioma with surgery in histologically confirmed cases 5 is not accurate and could mislead readers. By contrast, a subsequently published study including 33 gliomas, all treated with surgical resection and immunotherapy, identified astrocytomas and low-grade tumors were associated with increased survival. 8 Whereas the latter study findings result from univariable analysis ours resulted from univariable followed by multivariable Cox proportional hazard modeling. [...]differences between both studies' findings might be attributable to methodology of statistical analysis and lack of homogeneity of treatment modalities. [...]evidence based on larger case numbers and multivariable statistical analysis is necessary to confirm any association between glioma type or grade and prognosis in dogs. [...]we take this opportunity once again to invite researchers to contribute to the creation of a mutually accessible international multicenter database to better enable evidence-based research in the field of canine glioma.