Three sequential lymphomatous tumors in a patient

In 2016, 10 years after the initial diagnosis of Hodgkin's lymphoma, routine blood count showed elevated peripheral lymphocyte counts – an absolute lymphocyte count of 7.43 × 109 (usual range 0.94–3.08 × 109). A bone marrow examination was nondiagnostic, but flow cytometry demonstrated an abnor...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of dermatology 2018-09, Vol.63 (5), p.443-444, Article 443
Main Authors: Choi, Ellie, Yang, Sam, Tan, Kong, Aw, Derrick, Chandran, Nisha
Format: Article
Language:English
Subjects:
Bone marrow
Correspondence
Histology
Lymphoma
Patients
Tomography
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In 2016, 10 years after the initial diagnosis of Hodgkin's lymphoma, routine blood count showed elevated peripheral lymphocyte counts – an absolute lymphocyte count of 7.43 × 109 (usual range 0.94–3.08 × 109). A bone marrow examination was nondiagnostic, but flow cytometry demonstrated an abnormal population of postgerminal center memory B cells, with features consistent with a non-aggressive, small B cell lymphoma/leukemic (chronic lymphocytic leukemic vs marginal zone lymphoma). [1] Mechanisms postulated included immunosuppression from mutagenic effects of cytostatic drugs,[1] impaired T-cell immunity,[2] and underlying viral infection, e. g., human T-cell lymphotropic virus type 1,[3] and Epstein–Barr virus, assumed to be involved with the pathogenesis of B and T cell lymphomas.
ISSN:0019-5154
1998-3611
DOI:10.4103/ijd.IJD_424_17