Influence of High-Fat Diets Consumed During the Juvenile Period on Hippocampal Morphology and Function

The negative impact of obesity on neurocognitive functioning is an issue of increasing clinical interest. Over the last decade, a number of studies have analyzed the influence of high-fat diets (HFDs) on cognitive performance, particularly in adolescent individuals. Different approaches, including b...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cellular neuroscience 2018-11, Vol.12, p.439-439
Main Authors: Del Olmo, Nuria, Ruiz-Gayo, Mariano
Format: Article
Language:English
Subjects:
Animal cognition
Cell adhesion & migration
Cognition
Cognitive ability
Diet
Fatty acids
High fat diet
high-fat diets
Hippocampus
Inflammation
Insulin resistance
Learning
Leptin
Memory
Metabolism
Morphology
Neurogenesis
Neuroscience
Neurotransmission
Obesity
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The negative impact of obesity on neurocognitive functioning is an issue of increasing clinical interest. Over the last decade, a number of studies have analyzed the influence of high-fat diets (HFDs) on cognitive performance, particularly in adolescent individuals. Different approaches, including behavioral, neurochemical, electrophysiological and morphological studies, have been developed to address the effect of HFDs on neural processes interfering with learning and memory skills in rodents. Many of the studies have focused on learning and memory related to the hippocampus and the mechanisms underlying these processes. The goal of the current review article is to highlight the relationship between hippocampal learning/memory deficits and nutritional/endocrine inputs derived from HFDs consumption, with a special emphasis on research showing the effect of HFDs intake during the juvenile period. We have also reviewed recent research regarding the effect of HFDs on hippocampal neurotransmission. An overview of research suggesting the involvement of fatty acid (FA) receptor-mediated signaling pathways in memory deficits triggered by HFDs is also provided. Finally, the role of leptin and HFD-evoked hyperleptinemia is discussed.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2018.00439