Maternal exposure to arsenic in drinking water and risk of congenital heart disease in the offspring

[Display omitted] •Maternal exposure to arsenic is suspected to impair fetal health.•A dose-response association between maternal arsenic exposure and CHD was found.•Arsenic levels as low as 0.5–0.9 μg/L increased the risk of CHD.•Sex did not modify the association. Prenatal exposure to arsenic is s...

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Published in:Environment international 2022-02, Vol.160, p.107051-107051, Article 107051
Main Authors: Richter, Frida, Kloster, Stine, Wodschow, Kirstine, Hansen, Birgitte, Schullehner, Jörg, Kristiansen, Søren Munch, Petersen, Mette Mains, Strandberg-Larsen, Katrine, Ersbøll, Annette Kjær
Format: Article
Language:English
Subjects:
Arsenic
Arsenic - analysis
Arsenic - toxicity
Child
Cohort Studies
Congenital heart disease
Drinking water
Drinking Water - chemistry
Environmental Exposure - analysis
Environmental Exposure - statistics & numerical data
Female
Heart Defects, Congenital - chemically induced
Heart Defects, Congenital - epidemiology
Humans
Infant
Infant, Newborn
Male
Maternal exposure
Maternal Exposure - statistics & numerical data
Population-based individual-level registers
Pregnancy
Prenatal
Water Pollutants, Chemical - analysis
Water Pollutants, Chemical - toxicity
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Summary:[Display omitted] •Maternal exposure to arsenic is suspected to impair fetal health.•A dose-response association between maternal arsenic exposure and CHD was found.•Arsenic levels as low as 0.5–0.9 μg/L increased the risk of CHD.•Sex did not modify the association. Prenatal exposure to arsenic is suspected to impair fetal health, including congenital malformations. Few studies investigated an association between maternal exposure to arsenic and congenital heart disease. To examine the association between maternal exposure to arsenic through drinking water and congenital heart disease among offspring. This nationwide cohort study included all liveborn children in Denmark, 1997–2014. Maternal addresses at fetal age 4 weeks were linked to drinking water supply areas. Exposure was arsenic concentration in drinking water in first trimester in four categories (
ISSN:0160-4120
1873-6750
DOI:10.1016/j.envint.2021.107051