Highly Water-Dispersed Natural Fullerenes Coated with Pluronic Polymers as Novel Nanoantioxidants for Enhanced Antioxidant Activity

Fullerene is a cosmic material with a buckyball-like structure comprising 60 carbon atoms. It has attracted significant interest because of its outstanding antioxidant, antiviral, and antibacterial properties. Natural fullerene (NC60) in shungite meets the demand of biomedical fields to scavenge rea...

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Bibliographic Details
Published in:Antioxidants 2024-10, Vol.13 (10), p.1240
Main Authors: Oh, Hyeryeon, Lee, Jin Sil, Son, Panmo, Sim, Jooyoung, Park, Min Hee, Bang, Young Eun, Sung, Daekyung, Lim, Jong-Min, Choi, Won Il
Format: Article
Language:English
Subjects:
antioxidant
Antioxidants
Antiviral activity
Carbon
Coatings
colloidal stability
Drug delivery systems
fullerene
Fullerenes
Hydrophobicity
Molecular weight
Oxidative stress
Pluronic
Polymers
Reactive oxygen species
ROS scavenging
Solubilization
Water
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Summary:Fullerene is a cosmic material with a buckyball-like structure comprising 60 carbon atoms. It has attracted significant interest because of its outstanding antioxidant, antiviral, and antibacterial properties. Natural fullerene (NC60) in shungite meets the demand of biomedical fields to scavenge reactive oxygen species in many diseases. However, its hydrophobicity and poor solubility in water hinder its use as an antioxidant. In this study, highly water-dispersed and stable Pluronic-coated natural fullerene nanoaggregates (NC60/Plu) were prepared from various Pluronic polymers. The water dispersity and stability of NC60 were compared and optimized based on the characteristics of Pluronic polymers including F68, F127, L35, P123, and L81. In particular, NC60 coated with Pluronic F127 at a weight ratio of 1 to 5 showed excellent antioxidant effects both in situ and in vitro. This suggests that the high solubilization of NC60 in Pluronic polymers increases its chance of interacting with reactive oxygen radicals and improves radical scavenging activity. Thus, the optimized NC60/PF127 may be a novel biocompatible antioxidant for treating various diseases associated with oxidative stress.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox13101240