Melody: meta-analysis of microbiome association studies for discovering generalizable microbial signatures

Standard protocols for meta-analysis of association studies are inadequate for microbiome data due to their complex compositional structure, leading to inaccurate and unstable microbial signature selection. To address this issue, we introduce Melody, a framework that generates, harmonizes, and combi...

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Bibliographic Details
Published in:Genome Biology 2025-08, Vol.26 (1), p.245-245, Article 245
Main Authors: Wei, Zhoujingpeng, Chen, Guanhua, Tang, Zheng-Zheng
Format: Article
Language:English
Subjects:
Absolute abundance
Animal Genetics and Genomics
Best subset selection
Bioinformatics
Biomedical and Life Sciences
Colorectal carcinoma
colorectal neoplasms
Colorectal Neoplasms - microbiology
Compositional data
digestive system
Estimates
Evolutionary Biology
Gastrointestinal Microbiome
genome
Genomics
Human Genetics
Humans
Life Sciences
Meta-analysis
Metabolome
Methodology
Microbial Genetics and Genomics
microbiome
Microbiomes
Microbiota
Plant Genetics and Genomics
Quasi-multinomial model
Relative abundance
Sample size
Software
Sparsity
Statistical analysis
statistics
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