Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target

Abbreviations AC adenocarcinoma not otherwise specified CRC colorectal cancer DIA-MS data-independent acquisition mass spectrometry ECM extracellular matrix FFPE formalin-fixed paraffin-embedded IHC immunohistochemistry IPA ingenuity pathway analysis KO knockout MC mucinous carcinoma NC normal contr...

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Published in:Cancer communications (London, England) England), 2022-02, Vol.42 (2), p.164-169
Main Authors: Shao, Yingkuan, Xu, Kailun, Zheng, Xi, Zhou, Biting, Zhang, Xiuli, Wang, Lin, Sun, Yaoting, Li, Dan, Chen, Ting, Wang, Jian, Yu, Shaojun, Sun, Lifeng, Xu, Xiaoming, Dai, Shaozhi, Gao, Huanhuan, Ruan, Guan, Liu, Wei, Cai, Xue, Zhu, Tiansheng, Qi, Lina, Chen, Jiani, Hu, Wangxiong, Weng, Xingyue, Zhu, Yi, Xiang, Xueping, Hu, Zhiyuan, Li, Jinfan, Chen, Lirong, Shao, Jimin, Zheng, Shu, Guo, Tiannan
Format: Article
Language:English
Subjects:
Cell adhesion & migration
Cell growth
Cell Movement
Cluster analysis
Colorectal cancer
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - genetics
CRISPR
Enzymes
Extracellular matrix
Humans
Letter to the Editor
Letters to the Editor
Mass spectrometry
Patients
Phosphorylation
Polyps
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
Protein expression
Proteins
Proteomics
Scientific imaging
Tumors
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Summary:Abbreviations AC adenocarcinoma not otherwise specified CRC colorectal cancer DIA-MS data-independent acquisition mass spectrometry ECM extracellular matrix FFPE formalin-fixed paraffin-embedded IHC immunohistochemistry IPA ingenuity pathway analysis KO knockout MC mucinous carcinoma NC normal control PCT pressure cycling technology PDXs patient-derived xenografts PLOD2 Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 2 PRM parallel reaction monitoring TMA tissue microarray WB western blotting Dear editors, Colorectal cancer (CRC) is the second leading cause of cancer deaths in developed countries [ 1]. (B) Summary heatmap of expression of all dysregulated proteins in each group (hyperplastic polyps, adenomas, adenocarcinoma not otherwise specified and mucinous adenocarcinoma compared with the normal colon group, and enriched functional pathways of the differentially expressed proteins. NS, not significant We identified 928 differentially expressed proteins by comparing protein expression in samples from different CRC clinical stages to normal colon tissue samples (Figure 1B). Six biologically significant protein expression patterns associated with CRC development were selected by unsupervised cluster analysis.
ISSN:2523-3548
2523-3548
DOI:10.1002/cac2.12240