Maternal excess adiposity and serum 25-hydroxyvitamin D < 50 nmol/L are associated with elevated whole body fat mass in healthy breastfed neonates

• Published in: BMC pregnancy and childbirth 2022-01, Vol.22 (1), p.83-83, Article 83
• Main Authors: Razaghi, Maryam, Gharibeh, Nathalie, Vanstone, Catherine A, Sotunde, Olusola F, Wei, Shu Qin, McNally, Dayre, Rauch, Frank, Jones, Glenville, Weiler, Hope A
• Format: Article
• Language: English
• Subjects: Adipose Tissue; Adiposity; Adult; Babies; Body composition; Body fat; Body Mass Index; Breast Feeding; Breastfeeding & lactation; Female; Gestational age; Hospitals; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Laboratories; Male; Maternal Nutritional Physiological Phenomena; Mother-infant dyads; Mothers; Newborn babies; Nutrition research; Nutritional Status; Obstetrics; Pregnancy; Quality control; Quality standards; Quebec; Randomized Controlled Trials as Topic; Skin; Software; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D status
• ISSN: 1471-2393; 1471-2393
• DOI: 10.1186/s12884-022-04403-w

Vitamin D status of pregnant women is associated with body composition of the offspring. The objective of this study was to assess whether the association between maternal vitamin D status and neonatal adiposity is modified by maternal adiposity preconception. Healthy mothers and their term appropriate weight for gestational age (AGA) infants (n = 142; 59% male, Greater Montreal, March 2016-2019) were studied at birth and 1 month postpartum (2-6 weeks). Newborn (24-36 h) serum was collected to measure total 25-hydroxyvitamin D [25(OH)D] (immunoassay); maternal pre-pregnancy BMI was obtained from the medical record. Anthropometry, body composition (dual-energy X-ray absorptiometry) and serum 25(OH)D were measured at 2-6 weeks postpartum in mothers and infants. Mothers were grouped into 4 categories based on their vitamin D status (sufficient 25(OH)D ≥ 50 nmol/L vs. at risk of being insufficient