Liver magnetic resonance imaging, non-alcoholic fatty liver disease and metabolic syndrome risk in pre-pubertal Mexican boys

Rising global pediatric obesity rates, increase non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) prevalence, with MetS being a NAFLD risk factor. NAFLD can be asymptomatic, with liver function tests insensitive to mild disease, and liver biopsy, risking complications. Thus, we...

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Published in:Scientific reports 2024-10, Vol.14 (1), p.26104-12, Article 26104
Main Authors: de Celis Alonso, Benito, Shumbayawonda, Elizabeth, Beyer, Cayden, Hidalgo-Tobon, Silvia, López-Martínez, Briseida, Dies-Suarez, Pilar, Klunder-Klunder, Miguel, Miranda-Lora, América Liliana, Pérez, Eduardo Barragán, Thomaides-Brears, Helena, Banerjee, Rajarshi, Thomas, E. Louise, Bell, Jimmy D., So, Po-Wah
Format: Article
Language:English
Subjects:
692/163/2743/137/773
692/163/2743/2037
692/163/2743/2099
692/163/2743/393
692/4020/4021/1607/2750
BMI
Body Mass Index
Child
Humanities and Social Sciences
Humans
Liver - diagnostic imaging
Liver - pathology
Magnetic Resonance Imaging
Male
Metabolic syndrome
Metabolic Syndrome - diagnostic imaging
Metabolic Syndrome - epidemiology
Mexico - epidemiology
multidisciplinary
Multiparametric Magnetic Resonance Imaging
Multiparametric MRI
NAFLD
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - diagnostic imaging
Non-alcoholic Fatty Liver Disease - epidemiology
Obesity
Risk Factors
Science
Science (multidisciplinary)
Young children
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Summary:Rising global pediatric obesity rates, increase non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) prevalence, with MetS being a NAFLD risk factor. NAFLD can be asymptomatic, with liver function tests insensitive to mild disease, and liver biopsy, risking complications. Thus, we investigated multiparametric MRI (mpMRI) metrics of liver fat (proton density fat fraction, PDFF) and disease activity (fibro-inflammation; iron-corrected T1, cT1), in a Hispanic pre-pubertal pediatric cohort, with increased risk of NAFLD. Pre-pubertal boys (n = 81) of varying Body-Mass Index (BMI) were recruited in Mexico City. Most children (81%) had normal liver transaminase levels, 38% had high BMI, and 14% had ≥ 3 MetS risk factors. Applying mpMRI thresholds, 12%, 7% and 4% of the cohort had NAFLD, NASH and high-risk NASH respectively. Participants with ≥ 3 MetS risk factors had higher cT1 (834 ms vs. 737 ms, p = 0.004) and PDFF (8.7% vs. 2.2%, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-77307-8