A Comparative Analysis of NT-proBNP Levels in Pregnant Women and the Impact of SARS-CoV-2 Infection: Influence on Birth Outcome

The cardiac biomarker NT-proBNP is released by the ventricles in response to increased cardiac wall tension, showing cardiac activity in heart failure. The primary objective of this comparative study was to analyze the variations of NT-proBNP levels among pregnant patients and to determine the poten...

Full description

Saved in:
Bibliographic Details
Published in:Diseases 2024-01, Vol.12 (1), p.10
Main Authors: Marta, Carmen-Ioana, Craina, Marius, Nitu, Razvan, Maghiari, Anca Laura, Abu-Awwad, Simona-Alina, Boscu, Lioara, Diaconu, Mircea, Dumitru, Catalin, Dahma, George, Yasar, Ionela-Iasmina, Babes, Katalin
Format: Article
Language:English
Subjects:
Biomarkers
Birth
Brain natriuretic peptide
cardiovascular diseases
Causes of
Cesarean section
Comparative analysis
Complications and side effects
Confidentiality
Congestive heart failure
COVID-19
Enzyme-linked immunosorbent assay
Enzymes
Ethics
Health aspects
Heart failure
HIV
Human immunodeficiency virus
Immunology
Infections
Mortality
NT-proBNP
Perinatal infection
Physiological aspects
Pregnancy
pregnancy complications
Severe acute respiratory syndrome coronavirus 2
Substance abuse treatment
Viral infections
Womens health
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The cardiac biomarker NT-proBNP is released by the ventricles in response to increased cardiac wall tension, showing cardiac activity in heart failure. The primary objective of this comparative study was to analyze the variations of NT-proBNP levels among pregnant patients and to determine the potential influence of SARS-CoV-2 infection on these values. Secondly, the study focused on NT-proBNP levels and their influence on the type of birth. Blood samples were taken from 160 pregnant mothers in order to determine, through the solid-phase enzyme-linked immunosorbent assay (ELISA) method, the NT-proBNP concentrations from the plasma. The cohort was separated into two distinct groups based on SARS-CoV-2 diagnostic results: negative to the infection, and positive to the infection. The SARS-CoV-2-positive group of patients presented with higher levels of NT-proBNP and had higher rates of cesarean sections. (4) Conclusions: Our research highlights the crucial relationship between elevated NT-proBNP values and the mode of giving birth, natural delivery or cesarean section, and also the influence of SARS-CoV-2 viral infection and this biomarker.
ISSN:2079-9721
2079-9721
DOI:10.3390/diseases12010010