Adiposity and lipid metabolism indicators mediate the adverse effect of glucose metabolism indicators on oogenesis and embryogenesis in PCOS women undergoing IVF/ICSI cycles

Polycystic ovary syndrome (PCOS) women have high incidences of dyslipidemia, obesity, impaired glucose tolerance (IGT), diabetes, and insulin resistance (IR) and are fragile to female infertility. Obesity and dyslipidemia may be the intermediate biological mechanism for the associations between gluc...

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Bibliographic Details
Published in:European journal of medical research 2023-07, Vol.28 (1), p.216-216, Article 216
Main Authors: Jiang, Huahua, Si, Manfei, Tian, Tian, Shi, Huifeng, Huang, Ning, Chi, Hongbin, Yang, Rui, Long, Xiaoyu, Qiao, Jie
Format: Article
Language:English
Subjects:
Adiposity and lipid metabolism
Analysis
Binomial distribution
Body mass index
Cholesterol
Dextrose
Embryonic development
Embryos
Generalized linear models
Glucose
Glucose metabolism
Glucose metabolism indicators
Glycosylated hemoglobin
High density lipoprotein
Homeostasis
In vitro fertilization
Infertility
Insulin
Insulin resistance
IVF/ICSI outcomes
Lipids
Low density lipoproteins
Mediating effect
Mediation
Metabolic disorders
Metabolites
Morphology
Obesity
Ovaries
PCOS
Plasma
Polycystic ovary syndrome
Pregnancy
Sperm
Type 2 diabetes
Variables
Women
Womens health
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Summary:Polycystic ovary syndrome (PCOS) women have high incidences of dyslipidemia, obesity, impaired glucose tolerance (IGT), diabetes, and insulin resistance (IR) and are fragile to female infertility. Obesity and dyslipidemia may be the intermediate biological mechanism for the associations between glucose metabolism dysfunction and abnormal oogenesis and embryogenesis. This retrospective cohort study was performed at a university-affiliated reproductive center. A total of 917 PCOS women aged between 20 and 45 undergoing their first IVF/ICSI embryo transfer cycles from January 2018 to December 2020 were involved. Associations between glucose metabolism indicators, adiposity and lipid metabolism indicators, and IVF/ICSI outcomes were explored using multivariable generalized linear models. Mediation analyses were further performed to examine the potential mediation role of adiposity and lipid metabolism indicators. Significant dose-dependent relationships were found between glucose metabolism indicators and IVF/ICSI early reproductive outcomes and between glucose metabolism indicators and adiposity and lipid metabolism indicators (all P 
ISSN:2047-783X
0949-2321
2047-783X
DOI:10.1186/s40001-023-01174-8