Customizing cellular signal processing by synthetic multi-level regulatory circuits

As synthetic biology permeates society, the signal processing circuits in engineered living systems must be customized to meet practical demands. Towards this mission, novel regulatory mechanisms and genetic circuits with unprecedented complexity have been implemented over the past decade. These reg...

Full description

Saved in:
Bibliographic Details
Published in:Nature communications 2023-12, Vol.14 (1), p.8415-8415, Article 8415
Main Authors: Gao, Yuanli, Wang, Lei, Wang, Baojun
Format: Article
Language:English
Subjects:
38/39
631/553/2691
631/61/338/552
631/92/552
82/80
Biology
Boolean
Circuit design
Circuits
Computer engineering
Customization
Gene Regulatory Networks
Humanities and Social Sciences
Hybrid circuits
multidisciplinary
Regulatory mechanisms (biology)
Review
Review Article
Science
Science (multidisciplinary)
Sensors
Signal processing
Synthetic Biology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:As synthetic biology permeates society, the signal processing circuits in engineered living systems must be customized to meet practical demands. Towards this mission, novel regulatory mechanisms and genetic circuits with unprecedented complexity have been implemented over the past decade. These regulatory mechanisms, such as transcription and translation control, could be integrated into hybrid circuits termed “multi-level circuits”. The multi-level circuit design will tremendously benefit the current genetic circuit design paradigm, from modifying basic circuit dynamics to facilitating real-world applications, unleashing our capabilities to customize cellular signal processing and address global challenges through synthetic biology. As synthetic biology permeates society, the signal processing circuits in engineered living systems must be customized to meet practical demands. In this review, the authors outline design strategies for the DNA, RNA, and protein-level circuits and the hybrid “multi-level” circuits.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-44256-1