Loading…

Astaxanthin suppresses the metastasis of clear cell renal cell carcinoma through ROS scavenging

[Display omitted] •Astaxanthin blocks epithelial-mesenchymal transition of ccRCC cells.•Astaxanthin attenuates migratory and invasive activity of ccRCC cells.•The in vivo metastatic potential of ccRCC cells is suppressed by Astaxanthin.•Astaxanthin shows anti-metastatic activity through its ROS-scav...

Full description

Saved in:
Bibliographic Details
Published in:Journal of functional foods 2024-05, Vol.116, p.106139, Article 106139
Main Authors: Gong, Jun, Jiang, Suwei, Huang, Yuanbing, Yang, Dongxin, Zhang, Liang, Li, Zhenhai, Kang, Qingzheng
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Astaxanthin blocks epithelial-mesenchymal transition of ccRCC cells.•Astaxanthin attenuates migratory and invasive activity of ccRCC cells.•The in vivo metastatic potential of ccRCC cells is suppressed by Astaxanthin.•Astaxanthin shows anti-metastatic activity through its ROS-scavenging capacity. Clear cell renal cell carcinoma (ccRCC) represents a prevalent form of kidney cancer, and its poor prognosis is closely tied to the occurrence of metastasis. ROS can drive epithelial-mesenchymal transition (EMT), thereby promoting cancer metastasis. Astaxanthin (AXT), renowned for its exceptional antioxidant properties, has been shown in this study to suppress ccRCC metastasis by scavenging ROS. AXT dose-dependently reduced ROS levels and attenuated migratory and invasive capabilities of ccRCC cells. Additionally, ccRCC cells treated with AXT exhibited phenotypic characteristics indicating EMT inhibition, which was reflected by the increased E-cadherin and decreased vimentin. Furthermore, AXT-induced suppressed metastatic potential was also corroborated in mouse lung metastasis model. Notably, artificially elevating ROS levels reversed the AXT-induced reduction in migratory and invasive capacity. Taken together, these findings highlight the anti-metastatic function of AXT in ccRCC, suggesting its therapeutic potential in the management of ccRCC metastasis.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2024.106139