Bone Morphogenic Proteins in Pediatric Diffuse Midline Gliomas: How to Make New Out of Old?

The BMP pathway is one of the major signaling pathways in embryonic development, ontogeny and homeostasis, identified many years ago by pioneers in developmental biology. Evidence of the deregulation of its activity has also emerged in many cancers, with complex and sometimes opposing effects. Recen...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-03, Vol.25 (6), p.3361
Main Authors: Berthelot, Clément, Huchedé, Paul, Bertrand-Chapel, Adrien, Beuriat, Pierre-Aurélien, Leblond, Pierre, Castets, Marie
Format: Article
Language:English
Subjects:
Biochemistry, Molecular Biology
BMP
Bone Morphogenetic Proteins - metabolism
Brain cancer
Cancer
Child
Development and progression
Developmental biology
Diffuse Intrinsic Pontine Glioma - genetics
Diffuse Intrinsic Pontine Glioma - metabolism
Diffuse Intrinsic Pontine Glioma - pathology
DIPG
DMG
Embryonic development
Epigenetics
Genetic transcription
Genomics
Glioma
Glioma - metabolism
Gliomas
H3K27M
Histones - metabolism
Human health and pathology
Humans
Kinases
Life Sciences
Ligands
Methods
Mutation
Nervous system
Neurobiology
Neurogenesis
Neurons and Cognition
pediatric glioma
Pediatrics
Proteins
quiescence
Review
Signal Transduction
Tumors
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Summary:The BMP pathway is one of the major signaling pathways in embryonic development, ontogeny and homeostasis, identified many years ago by pioneers in developmental biology. Evidence of the deregulation of its activity has also emerged in many cancers, with complex and sometimes opposing effects. Recently, its role has been suspected in Diffuse Midline Gliomas (DMG), among which Diffuse Intrinsic Pontine Gliomas (DIPG) are one of the most complex challenges in pediatric oncology. Genomic sequencing has led to understanding part of their molecular etiology, with the identification of histone H3 mutations in a large proportion of patients. The epigenetic remodeling associated with these genetic alterations has also been precisely described, creating a permissive context for oncogenic transcriptional program activation. This review aims to describe the new findings about the involvement of BMP pathway activation in these tumors, placing their appearance in a developmental context. Targeting the oncogenic synergy resulting from this pathway activation in an H3K27M context could offer new therapeutic perspectives based on targeting treatment-resistant cell states.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25063361