Comparative analysis of the hemostatic, analgesic and healing effects of cyanoacrylate on free gingival graft surgical wounds in donor and recipient areas: a systematic review

• Published in: Journal of materials science. Materials in medicine 2021-09, Vol.32 (9), p.98-98, Article 98
• Main Authors: Veríssimo, Aretha Heitor, Ribeiro, Anne Kaline Claudino, Martins, Ana Rafaela Luz de Aquino, Gurgel, Bruno Cesar de Vasconcelos, Lins, Ruthineia Diógenes Alves Uchoa
• Format: Article
• Language: English
• Subjects: Analgesia; Analgesics; Analgesics - pharmacology; Autografts; Bandages; Bias; Biocompatibility Studies; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical materials; Bleeding; Ceramics; Chemistry and Materials Science; Comparative analysis; Composites; Cyanoacrylates; Cyanoacrylates - pharmacology; Decision making; Dentistry; Evaluation; Fibrin; Gingiva; Gingiva - transplantation; Glass; Grafting; Hemostasis; Hemostatics; Hemostatics - pharmacology; Heterogeneity; Humans; Inflammation; Inflammatory response; Materials Science; Natural Materials; Pain; Pain perception; Palate; Palate - surgery; Patients; Periodontal surgery; Platelet-Rich Fibrin; Polymer Sciences; Quality assessment; Re-Epithelialization - drug effects; Reconstructive Surgical Procedures; Regenerative Medicine/Tissue Engineering; Risk; Soft tissues; Surfaces and Interfaces; Surgery; Surgical Wound; Thin Films; Wound Healing; Wounds
• ISSN: 0957-4530; 1573-4838
• DOI: 10.1007/s10856-021-06573-z

To analyze the hemostatic, Dsurgical wounds in donor and recipient areas of free gingival grafts (FGG). Five databases (PubMed, Scopus, Science Direct, Cochrane and Web of Science) were searched up to March 2021 (PROSPERO CRD42019134497). The focus of the study (cyanoacrylate) was combined with the condition (periodontal surgery OR free gingival graft OR free soft tissue graft OR autografts), and outcome (healing OR epithelialization OR pain OR analgesia OR bleeding OR hemostasis OR hemostatic). Studies reporting cyanoacrylate isolated or associated with another substance in FGG stabilization and closure were investigated and assessed for the quality and risk of bias through the Cochrane Manual. Six studies with 323 participants were included. Evaluation of the quality and risk of bias highlighted a low risk for four articles, intermediate for one and unclear for another. The use of cyanoacrylate associated or not with the hemostatic sponge or the platelet-rich fibrin was more effective in healing (three studies), analgesia (four studies), and hemostasis in one study ( p