Spatially resolved cell atlas of the teleost telencephalon and deep homology of the vertebrate forebrain

The telencephalon has undergone remarkable diversification and expansion throughout vertebrate evolution, exhibiting striking variations in structural and functional complexity. Nevertheless, fundamental features are shared across vertebrate taxa, such as the presence of distinct regions including t...

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Bibliographic Details
Published in:Communications biology 2024-05, Vol.7 (1), p.612-16, Article 612
Main Authors: Hegarty, Brianna E., Gruenhagen, George W., Johnson, Zachary V., Baker, Cristina M., Streelman, Jeffrey T.
Format: Article
Language:English
Subjects:
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Animals
Biological Evolution
Biomedical and Life Sciences
Cichlids - genetics
Evolution
Forebrain
Hippocampus
Homology
Life Sciences
Pallium
Prosencephalon - cytology
Reptiles & amphibians
Structure-function relationships
Telencephalon
Telencephalon - cytology
Transcription
Transcriptome
Transcriptomics
Vertebrates
Vertebrates - genetics
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Summary:The telencephalon has undergone remarkable diversification and expansion throughout vertebrate evolution, exhibiting striking variations in structural and functional complexity. Nevertheless, fundamental features are shared across vertebrate taxa, such as the presence of distinct regions including the pallium, subpallium, and olfactory structures. Teleost fishes have a uniquely “everted” telencephalon, which has confounded comparisons of their brain regions to other vertebrates. Here we combine spatial transcriptomics and single nucleus RNA-sequencing to generate a spatially-resolved transcriptional atlas of the Mchenga conophorus cichlid fish telencephalon. We then compare cell-types and anatomical regions in the cichlid telencephalon with those in amphibians, reptiles, birds, and mammals. We uncover striking transcriptional similarities between cell-types in the fish telencephalon and subpallial, hippocampal, and cortical cell-types in tetrapods, and find support for partial eversion of the teleost telencephalon. Ultimately, our work lends new insights into the organization and evolution of conserved cell-types and regions in the vertebrate forebrain. Single nucleus RNA-seq and spatial transcriptomics reveal a detailed picture of the cichlid fish forebrain. Comparisons with atlases in other vertebrates uncover striking transcriptional similarities and lend new insights into forebrain evolution.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-024-06315-1