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Gender differences in the association between body mass index and recent suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder

Controversial evidence exists on the relationship between body mass index (BMI) and suicide attempts (SA) in patients with major depressive disorder (MDD). This cross-sectional study aimed to explore the association between BMI and SA in first-episode drug-naïve (FEDN) MDD patients in China. The stu...

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Published in:Scientific reports 2023-09, Vol.13 (1), p.16033-16033, Article 16033
Main Authors: Liu, Junjun, Li, Zhe, Jia, Fengnan, Yuan, Hsinsung, Zhou, Yue, Xia, Xingzhi, Yang, Ruchang, Wu, Yuxuan, Zhang, Xiaobin, Ye, Gang, Du, Xiangdong, Zhang, Xiangyang
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Language:English
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Summary:Controversial evidence exists on the relationship between body mass index (BMI) and suicide attempts (SA) in patients with major depressive disorder (MDD). This cross-sectional study aimed to explore the association between BMI and SA in first-episode drug-naïve (FEDN) MDD patients in China. The study was conducted from 2016 to 2018 in Taiyuan, China. Univariate and multivariate logistic regression analyzed the BMI–SA association, with subgroup analysis for gender. Threshold effects were examined using two-piecewise regression. In males, BMI was significantly associated with SA (OR = 0.84, 95% CI 0.74–0.94, P  = 0.003) after full adjustment, but not in females (OR = 0.97, 95% CI 0.89–1.06, P  = 0.541). The interaction with gender was significant ( P for interaction 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-43166-y