Healthy Breastfeeding Infants Consume Different Quantities of Milk Fat Globule Membrane Lipids

The human milk fat globule membrane (MFGM) contains important lipids for growing infants. Anthropometric measurements, milk samples, and infant milk intake were collected in a cohort of eleven healthy mother–infant dyads during exclusive breastfeeding from birth to six months. One hundred and sixty-...

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Bibliographic Details
Published in:Nutrients 2021-08, Vol.13 (9), p.2951
Main Authors: George, Alexandra D., Gay, Melvin C. L., Selvalatchmanan, Jayashree, Torta, Federico, Bendt, Anne K., Wenk, Markus R., Murray, Kevin, Wlodek, Mary E., Geddes, Donna T.
Format: Article
Language:English
Subjects:
Animal fat
Babies
Breast feeding
Breast milk
breastfeeding
Breastfeeding & lactation
breastmilk
Discriminant analysis
fat
Gestational age
human milk
Infant formulas
Infants
lactation
lipidomics
Lipids
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Membranes
Milk
Milk fat globule membranes
Mothers
Oils & fats
Phospholipids
Software
Solvents
Standard deviation
Womens health
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Summary:The human milk fat globule membrane (MFGM) contains important lipids for growing infants. Anthropometric measurements, milk samples, and infant milk intake were collected in a cohort of eleven healthy mother–infant dyads during exclusive breastfeeding from birth to six months. One hundred and sixty-six MFGM lipids were analysed using liquid chromatography-mass spectrometry, and the infant intake was calculated. The concentrations and intake were compared and associations between infant intake and growth characteristics explored. The lipid concentrations and infant intake varied widely between mother–infant dyads and between months one and three. The infant intake for many species displayed positive correlations with infant growth, particularly phospholipid species. The high variation in lipid intake is likely an important factor in infant growth, with strong correlations identified between the intake of many MFGM lipids and infant head circumference and weight. This study highlights the need for intake measurements and inclusion in cohort studies to elucidate the role of the human milk lipidome in infant growth and development.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13092951