Comparison of dorsal penile nerve block alone and in combination with lidocaine–prilocaine cream in neonates undergoing circumcision: a randomized controlled study

• Published in: World journal of pediatric surgery 2022-11, Vol.5 (4), p.e000470-e000470
• Main Authors: Ogundele, Ibukunolu Olufemi, Nwokoro, Chigbundu Collins, Adedeji, Tewogbade Adeoye, Igwe, Arua Obasi, Adumah, Collins Chijioke, Talabi, Ademola Olusegun, Shonubi, Aderibigbe Modupe, Sowande, Oludayo Adedapo
• Format: Article
• Language: English
• Subjects: Analgesia; Anesthetics; Circumcision; Hormones; Neonatology; Original Research; Pain; Pediatrics; Penis
• ISSN: 2516-5410; 2096-6938; 2516-5410
• DOI: 10.1136/wjps-2022-000470

BackgroundSuboptimal neonatal circumcision analgesia causes a significant stress response. There is continued search for more effective analgesia for neonatal circumcision. We aimed to determine whether lidocaine–prilocaine cream (LPC) prior to dorsal penile nerve block (DPNB) offers better analgesia than DPNB alone.MethodsA prospective randomized study of 72 neonates undergoing plastibell circumcision was randomized into two groups of 36 each. Group I received DPNB alone with 4 mg/kg plain lidocaine. Group II had 1 g LPC applied to the phallus 1 hour before DPNB. Serum cortisol levels were measured 30 min preoperatively and 30 min postoperatively. Heart rate (HR) and peripheral arterial oxygen saturation (SpO2) were noted at 30 min preoperatively, after DPNB injection, after excising the prepuce, and at 30 min thereafter. The primary outcome measure was change in serum cortisol levels, while secondary outcomes were changes in HR and SpO2.ResultsBoth groups had increased mean serum cortisol levels, decreased mean SpO2 and increased mean HR from baseline. The rise in mean serum cortisol level was significantly lower in group II (8.09±4.53 µg/dL) than that in group I (11.42±7.83 µg/dL) (p=0.034). Changes in SpO2 and HR were significantly less in group II than that in group I patients (p