Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease

The perinatal period is crucial to the establishment of lifelong gut microbiota. The abundance and composition of microbiota can be altered by several factors such as preterm delivery, formula feeding, infections, antibiotic treatment, and lifestyle during pregnancy. Gut dysbiosis affects the develo...

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Bibliographic Details
Published in:Nutrients 2020-07, Vol.12 (8), p.2243
Main Authors: Navarro-Tapia, Elisabet, Sebastiani, Giorgia, Sailer, Sebastian, Toledano, Laura Almeida, Serra-Delgado, Mariona, García-Algar, Óscar, Andreu-Fernández, Vicente
Format: Article
Language:English
Subjects:
Adaptive immunity
antibiotic resistance
Antibiotics
atopic diseases
Atopy
autoimmune diseases
Bias
Dysbacteriosis
dysbiosis
Dysbiosis - microbiology
Dysbiosis - prevention & control
Enterocolitis
Enterocolitis, Necrotizing - microbiology
Enterocolitis, Necrotizing - prevention & control
Female
Food allergies
Gastrointestinal diseases
Gastrointestinal Microbiome
gut microbiota
Health services
Humans
Immune response
Infant
Infant, Newborn
Infant, Newborn, Diseases - microbiology
Infant, Newborn, Diseases - prevention & control
Infants
Infections
Intestinal microflora
Male
Medical treatment
Microbiota
Necrosis
Necrotizing enterocolitis
Neonates
Newborn babies
Perinatal Care - methods
Pregnancy
Probiotics
Probiotics - therapeutic use
Review
Womens health
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Summary:The perinatal period is crucial to the establishment of lifelong gut microbiota. The abundance and composition of microbiota can be altered by several factors such as preterm delivery, formula feeding, infections, antibiotic treatment, and lifestyle during pregnancy. Gut dysbiosis affects the development of innate and adaptive immune responses and resistance to pathogens, promoting atopic diseases, food sensitization, and infections such as necrotizing enterocolitis (NEC). Recent studies have indicated that the gut microbiota imbalance can be restored after a single or multi-strain probiotic supplementation, especially mixtures of and strains. Following the systematic search methodology, the current review addresses the importance of probiotics as a preventive or therapeutic tool for dysbiosis produced during the perinatal and infant period. We also discuss the safety of the use of probiotics in pregnant women, preterm neonates, or infants for the treatment of atopic diseases and infections.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu12082243