Association between MMP2 gene polymorphisms and dilated cardiomyopathy in a Chinese Han population

Aims Dilated cardiomyopathy (DCM) belongs to the common types of cardiomyopathies. The pathogenesis remains unclear despite the fact that various genes have been found associated with DCM. MMP2 is a zinc‐dependent and calcium‐containing secreted endoproteinases, which could cleave a broad spectrum o...

Full description

Saved in:
Bibliographic Details
Published in:ESC Heart Failure 2023-06, Vol.10 (3), p.1793-1802
Main Authors: Li, Shiyang, Zeng, Xiaobin, Wang, Shihai, Xie, Xiaoshuang, Lan, Jianjun
Format: Article
Language:English
Subjects:
Blood pressure
Cancer
Cardiomyopathy
Cardiomyopathy, Dilated - genetics
Cardiomyopathy, Dilated - pathology
Cardiovascular disease
Cell culture
Congenital diseases
Dilated cardiomyopathy
East Asian People
Ejection fraction
Enzymes
Genes
Genomes
Heart rate
Humans
Hypertension
Matrix Metalloproteinase 2 - genetics
MMP2
Mortality
Original
Pathogenesis
Plasmids
Polymorphism, Single Nucleotide
Polymorphisms
Prognosis
Repressor Proteins - genetics
Stroke Volume
Susceptibility
Ventricular Function, Left
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims Dilated cardiomyopathy (DCM) belongs to the common types of cardiomyopathies. The pathogenesis remains unclear despite the fact that various genes have been found associated with DCM. MMP2 is a zinc‐dependent and calcium‐containing secreted endoproteinases, which could cleave a broad spectrum of substrates including extracellular matrix components and cytokines. It has proved to play an important role in the cardiovascular diseases. This study aimed to investigate the potential role of MMP2 gene polymorphisms in DCM susceptibility and prognosis in a Chinese Han population. Methods and results A total of 600 idiopathic DCM patients and 700 healthy controls were enrolled. Patients with contact information were followed up for a median period of 28 months. Three tagged single nucleotide polymorphisms (rs243865, rs2285052, and rs2285053) in the promoter of MMP2 gene were genotyped. A series of function analysis were conducted to illuminate the underlying mechanism. The frequency of rs243865‐C allele was increased in DCM patients when compared with healthy controls (P = 0.001). Genotypic frequencies of rs243865 were associated with the susceptibility of DCM in the codominant, dominant, and overdominant models (P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.14333