Myeloid response evaluated by noninvasive CT imaging predicts post-surgical survival and immune checkpoint therapy benefits in patients with hepatocellular carcinoma

• Published in: Frontiers in immunology 2024, Vol.15, p.1493735
• Main Authors: Peng, Kangqiang, Zhang, Xiao, Li, Zhongliang, Wang, Yongchun, Sun, Hong-Wei, Zhao, Wei, Pan, Jielin, Zhang, Xiao-Yang, Wu, Xiaoling, Yu, Xiangrong, Wu, Chong, Weng, Yulan, Lin, Xiaowen, Liu, Dingjie, Zhan, Meixiao, Xu, Jing, Zheng, Limin, Zhang, Yaojun, Lu, Ligong
• Format: Article
• Language: English
• Subjects: Adult; Aged; Carcinoma, Hepatocellular - diagnostic imaging; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - therapy; Female; hepatocellular carcinoma; Humans; Immune Checkpoint Inhibitors - therapeutic use; Immunology; immunotherapy; Immunotherapy - methods; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - immunology; Liver Neoplasms - mortality; Liver Neoplasms - therapy; Male; Middle Aged; myeloid cells; Myeloid Cells - immunology; Nomograms; Prognosis; radiomics; Retrospective Studies; Tomography, X-Ray Computed - methods
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2024.1493735

The potential of preoperative CT in the assessment of myeloid immune response and its application in predicting prognosis and immune-checkpoint therapy outcomes in hepatocellular carcinoma (HCC) has not been explored. A total of 165 patients with pathological slides and multi-phase CT images were included to develop a radiomics signature for predicting the imaging-based myeloid response score (iMRS). Overall survival (OS) and recurrence-free survival (RFS) were assessed according to the iMRS risk group and validated in a surgical resection cohort ( = 98). The complementary advantage of iMRS incorporating significant clinicopathologic factors was investigated by the Cox proportional hazards analysis. Additionally, the iMRS in inferring the benefits of immune checkpoint therapy was explored in an immunotherapy cohort ( = 36). We showed that AUCs of the optimal radiomics signature for iMRS were 0.941 [95% confidence interval (CI), 0.909-0.973] and 0.833 (0.798-0.868) in the training and test cohorts, respectively. High iMRS was associated with poor RFS and OS. The prognostic performance of the Clinical-iMRS nomogram was better than that of a single parameter ( < 0.05), with a 1-, 3-, and 5-year C-index for RFS of 0.729, 0.709, and 0.713 in the training, test, and surgical resection cohorts, respectively. A high iMRS score predicted a higher proportion of objective response (vs. progressive disease or stable disease; odds ratio, 2.311; 95% CI, 1.144-4.672; = 0.020; AUC, 0.718) in patients treated with anti-PD-1 and PD-L1. iMRS may provide a promising method for predicting local myeloid immune responses in HCC patients, inferring postsurgical prognosis, and evaluating benefits of immune checkpoint therapy.