Towards zero mortality in sickle cell pregnancy: A prospective study comparing haemoglobin SS and AA women in Lagos, Nigeria

Introduction: Sickle cell disease in pregnancy carries increased risk of maternal and perinatal morbidity and mortality. Past studies on pregnancy complications in sickle cell disease women were limited by relatively small sample sizes, and use of retrospective and hospital discharge data. Study Des...

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Bibliographic Details
Published in:The Nigerian postgraduate medical journal 2019-01, Vol.26 (1), p.1-7
Main Authors: Babah, Ochuwa, Aderolu, Monsurat, Oluwole, Ayodeji, Afolabi, Bosede
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Anemia, Sickle Cell - complications
Anemia, Sickle Cell - mortality
Birth weight
Blood pressure
Case-Control Studies
complications
Female
Genotype & phenotype
haemoglobin aa
haemoglobin ss
Hemoglobin
Hemoglobin A
Hemoglobin, Sickle
Humans
Hypertension
Maternal Mortality
maternal outcome
Mortality
Nigeria - epidemiology
perinatal outcome
Population
Preeclampsia
Pregnancy
Pregnancy complications
Pregnancy Complications, Hematologic - blood
Pregnancy Complications, Hematologic - mortality
Pregnancy Outcome
Prenatal care
Prospective Studies
Sickle cell anemia
sickle cell disease pregnancy
Studies
Womens health
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Summary:Introduction: Sickle cell disease in pregnancy carries increased risk of maternal and perinatal morbidity and mortality. Past studies on pregnancy complications in sickle cell disease women were limited by relatively small sample sizes, and use of retrospective and hospital discharge data. Study Design: This prospective case-control study compared booked pregnant Haemoglobin (Hb) SS women with AA controls from two tertiary centres in Lagos, in order to precisely identify their complication and mortality rates and identify associated factors. Eligible pregnant HbSS and HbAA women were recruited from antenatal clinics at booking and follow-up visits. Information was collected on a proforma and data was analyzed using IBM SPSS version 20. Results: We found higher complication rate in HbSS group, commonest complications being vaso-occlusive crisis (RR 1.47, 95% CI 1.22 - 1.78), pregnancy induced hypertension (RR 1.31, 95% CI 1.08 - 1.57), urinary tract infection (RR 1.32, 95% CI 1.12 - 1.57), and intrauterine growth restriction (RR 1.2, 95% CI 1.05 - 1.34). HbSS group had higher systolic and mean arterial blood pressure values in early puerperium compared to HbAA group (p = 0.014 and 0.024 respectively). No maternal death recorded in both group. Incidence of low birth weight
ISSN:1117-1936
2468-6875
DOI:10.4103/npmj.npmj_177_18