From pattern separation to mood regulation: multiple roles for developmental signals in the adult dentate gyrus

[...]the assertion that mature granule cells are either inactive, or very finely tuned to specific spatial configurations, is derived from electrophysiological recording experiments and measures of immediate early gene expression conducted under conditions that are not likely to evoke significant ps...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2013, Vol.7, p.96-96
Main Authors: Wosiski-Kuhn, Marlena, Stranahan, Alexis M
Format: Article
Language:English
Subjects:
Amygdala
Dentate Gyrus
Electrophysiological recording
Excitability
Fear conditioning
Gene expression
Granule cells
Hippocampus
Immediate-early proteins
Influence
Innervation
MAP kinase
Memory
Mood
Morphology
Neurogenesis
Neurons
Neuroscience
Neurosciences
Pattern Separation
Physiology
Population
Recruitment
reelin
Reelin protein
stress
Synaptic plasticity
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Summary:[...]the assertion that mature granule cells are either inactive, or very finely tuned to specific spatial configurations, is derived from electrophysiological recording experiments and measures of immediate early gene expression conducted under conditions that are not likely to evoke significant psychological or physiological stress. Dendritic architecture varies with position in the granule cell layer (Desmond and Levy, 1982; Claiborne et al., 1990; Redila and Christie, 2006) and granule cells born in adulthood are deeper in the granule cell layer than those born in development. [...]the functional contributions of new neurons may arise from the properties of the subgranular zone microenvironment rather than their excitability or a potential signaling mechanism impacting the larger population of mature dentate granule cells. Vascular innervation of the subgranular zone is substantially more dense than the granule cell layer or molecular layer of the dentate gyrus (Monje et al., 2003), opening the possibility that new neurons might exhibit distinct patterns of neurovascular coupling based on their greater spatial proximity to blood vessels. Fear conditioning tasks are dependent on both basolateral amygdala (BLA) and hippocampus, as seen in cooperative induction of MAPK/ERK signaling components and immediate early genes in the hippocampus and amygdala following contextual fear conditioning and retrieval (Maren, 1996; Maren et al., 1996; Goosens and Maren, 2001; Roozendaal et al., 2009). [...]the specific contributions of new neurons to fear conditioning tasks could arise from differential innervation of new and mature neurons by the amygdala.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2013.00096