Association between gut microbiota and gastrointestinal cancer: a two-sample bi-directional Mendelian randomization study

The gut microbiome is closely related to gastrointestinal (GI) cancer, but the causality of gut microbiome with GI cancer has yet to be fully established. We conducted this two-sample Mendelian randomization (MR) study to reveal the potential causal effect of gut microbiota on GI cancer. Summary-lev...

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Bibliographic Details
Published in:Frontiers in microbiology 2023-07, Vol.14, p.1181328-1181328
Main Authors: Su, Qing, Jin, Chen, Bo, Zhiyuan, Yang, Yi, Wang, Jingxian, Wang, Juejin, Zhou, Junxi, Chen, Yaqing, Zeng, Hao, Chen, Gang, Wang, Yi
Format: Article
Language:English
Subjects:
causal relationship
gastrointestinal cancer
gut microbiota
instrumental variable
Mendelian randomization
Microbiology
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Summary:The gut microbiome is closely related to gastrointestinal (GI) cancer, but the causality of gut microbiome with GI cancer has yet to be fully established. We conducted this two-sample Mendelian randomization (MR) study to reveal the potential causal effect of gut microbiota on GI cancer. Summary-level genetic data of gut microbiome were derived from the MiBioGen consortium and the Dutch Microbiome Project. Summary statistics of six GI cancers were drawn from United Kingdom Biobank. Inverse-variance-weighted (IVW), MR-robust adjusted profile score (MR-RAPS), and weighted-median (WM) methods were used to evaluate the potential causal link between gut microbiota and GI cancer. In addition, we performed sensitivity analyses and reverse MR analyses. We identified potential causal associations between 21 bacterial taxa and GI cancers (values of
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2023.1181328