Responsiveness of PROMIS® to change in chronic obstructive pulmonary disease

Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease characterized by airflow obstruction that leads to shortness of breath and substantial negative impacts on health-related quality of life (HRQL). The course of COPD includes periodic acute exacerbations that req...

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Bibliographic Details
Published in:Journal of patient-reported outcomes 2019-10, Vol.3 (1), p.65-13, Article 65
Main Authors: Yount, Susan E., Atwood, Charles, Donohue, James, Hays, Ron D., Irwin, Debra, Leidy, Nancy Kline, Liu, Honghu, Spritzer, Karen L., DeWalt, Darren A.
Format: Article
Language:English
Subjects:
Anxiety
Chronic illnesses
Chronic obstructive pulmonary disease
COPD
Dyspnea
Medicine
Medicine & Public Health
Patient-reported outcomes
PROMIS
Quality of Life Research
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Summary:Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease characterized by airflow obstruction that leads to shortness of breath and substantial negative impacts on health-related quality of life (HRQL). The course of COPD includes periodic acute exacerbations that require changes in treatment and/or hospitalizations. This study was designed to examine the responsiveness of Patient-Reported Outcomes Measurement Information System® (PROMIS®) measures to changes associated with COPD exacerbation recovery. Methods A longitudinal analysis using mixed-effects models was conducted of people who were enrolled while stable ( n  = 100) and those who experienced an acute exacerbation ( n  = 85). PROMIS (physical function, pain interference, pain behavior, fatigue, anxiety, depression, anger, social roles, discretionary social activities, Global Health, dyspnea severity and dyspnea functional limitations) and COPD-targeted HRQL measures were completed at baseline and at 12 weeks. Results We administered PROMIS measures using computer adaptive testing (CAT), followed by administration of any remaining short form (SF) items that had not yet been administered by CAT. Examination of the difference between group differences from baseline to 12 weeks in the stable and exacerbation groups revealed that the exacerbation group changed (improved) significantly more than the stable group in anxiety ( p  
ISSN:2509-8020
2509-8020
DOI:10.1186/s41687-019-0155-9