Brassica oleracea Prevents HCl/Ethanol-Induced Gastric Damages in Mice

Brassica oleracea var. capitata L. (cabbage) is a popular vegetable with a wide range of pharmacological activities that help to promote human health. The present study investigated the beneficial effects of B. oleracea var. capitata L. extract (BOE) on HCl/ethanol (H/E)-induced gastric damages in m...

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Bibliographic Details
Published in:Applied sciences 2021-01, Vol.11 (1), p.16
Main Authors: Kim, Mi-Ryung, Kim, Tae-Il, Choi, Beom-Rak, Kim, Moon Bong, Cho, Il Je, Lee, Keun-Woo, Ku, Sae Kwang
Format: Article
Language:English
Subjects:
Alcohol
anti-inflammation
Anti-inflammatory agents
antioxidant
Antioxidants
Brassica oleracea
Brassica oleracea var. capitata L. extract (BOE)
Chromatography
Collagen
Cytokines
Enzymatic activity
Enzyme activity
Ethanol
Gastric juice
Gastric mucosa
Gene expression
Glycoproteins
HCl/ethanol (H/E)-induced gastric damage
Hexose
Histamine
Inflammation
Laboratory animals
Lesions
Malondialdehyde
mRNA
Oxidative stress
Peroxidase
Tissues
Tumor necrosis factor-TNF
Ulcers
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Summary:Brassica oleracea var. capitata L. (cabbage) is a popular vegetable with a wide range of pharmacological activities that help to promote human health. The present study investigated the beneficial effects of B. oleracea var. capitata L. extract (BOE) on HCl/ethanol (H/E)-induced gastric damages in mice. Pre-administration of BOE (25–100 mg/kg) for 7 consecutive days significantly decreased macroscopically visible lesion on the gastric mucosa induced by H/E. In addition, results from hematoxylin and eosin-stained gastric tissue showed that BOE inhibited invaded percentage of lesion and prevented the reduction in mucosal thickness in peri-ulcerative region. BOE significantly alleviated the H/E-mediated decreases in Alcian blue binding, total hexose, sialic acid, and collagen in the gastric tissue, suggesting BOE attenuates the gastric damage via preserving the integrity of gastric mucus. Moreover, BOE significantly decreased histamine level in the plasma and reduced mRNA levels associated with secreting gastric acid. Furthermore, BOE inhibited myeloperoxidase activity and suppressed nuclear factor-κB mRNA and its dependent inflammatory genes expression induced by H/E. BOE also strengthened antioxidant enzyme activity, with a mitigating H/E-mediated increase in malondialdehyde level of the gastric tissue. Thus, these results suggest that BOE has the potential to protect the gastric tissue via inhibiting gastric acid secretion, inflammation, and oxidative stress.
ISSN:2076-3417
2076-3417
DOI:10.3390/app11010016