Engineering Multifunctional Hydrogel With Osteogenic Capacity for Critical-Size Segmental Bone Defect Repair

Treating critical-size segmental bone defects is an arduous challenge in clinical work. Preparation of bone graft substitutes with notable osteoinductive properties is a feasible strategy for critical-size bone defects. Herein, a biocompatible hydrogel was designed by dynamic supramolecular assembly...

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Bibliographic Details
Published in:Frontiers in bioengineering and biotechnology 2022-05, Vol.10, p.899457-899457
Main Authors: Zheng, Shaowei, Zhong, Haobo, Cheng, Hao, Li, Xu, Zeng, Guowei, Chen, Tianyu, Zou, Yucong, Liu, Weile, Sun, Chunhan
Format: Article
Language:English
Subjects:
Bioengineering and Biotechnology
BMSCs
bone regeneration
critical bone defect
hydrogel
osteogenic differentiation
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Summary:Treating critical-size segmental bone defects is an arduous challenge in clinical work. Preparation of bone graft substitutes with notable osteoinductive properties is a feasible strategy for critical-size bone defects. Herein, a biocompatible hydrogel was designed by dynamic supramolecular assembly of polyvinyl alcohol (PVA), sodium tetraborate (Na B O ), and tetraethyl orthosilicate (TEOS). The characteristics of the supramolecular hydrogel were evaluated by rheological analysis, swelling ratio, degradation experiments, and scanning electron microscopy (SEM). In experiments, this TEOS-hydrogel had self-healing property, low swelling rate, degradability, good biocompatibility, and induced osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by upregulating the expression of Runx-2, Col-1, OCN, and osteopontin (OPN). In segmental bone defect rabbit models, the TEOS-containing hydrogel accelerated bone regeneration, thus restoring the continuity of bone and recanalization of the medullary cavity. The abovementioned results demonstrated that this TEOS-hydrogel has the potential to realize bone healing in critical-size segmental bone defects.
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.899457