Timescales of learning in the basal ganglia and the hippocampus

When the rat explores an environment theta oscillations lead to a weak (protein synthesis independent) form of long term potentiation (LTP), determining relatively short (1–3 h) changes in the involved synaptic efficacies. The failure to learn from delayed feedback in patients with hippocampal lesio...

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Bibliographic Details
Published in:Frontiers in behavioral neuroscience 2013-08, Vol.7, p.98-98
Main Authors: Ortu, Daniele, Skavhaug, Ida M, Vaidya, Manish
Format: Article
Language:English
Subjects:
Basal Ganglia
Behavior
Brain research
Delayed feedback
Dopamine
Dopamine receptors
Feedback
Hippocampus
Laboratories
Learning
Movement disorders
Neostriatum
Neurodegenerative diseases
Neuroscience
Parkinson's disease
Reinforcement
reinforcement learning
Ventral Tegmental Area
Ventral tegmentum
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Summary:When the rat explores an environment theta oscillations lead to a weak (protein synthesis independent) form of long term potentiation (LTP), determining relatively short (1–3 h) changes in the involved synaptic efficacies. The failure to learn from delayed feedback in patients with hippocampal lesions could be related to the loss of function of area CA1, since CA1 receives afferents from areas known to respond phasically to reinforcing stimulation (Gasbarri et al., 1994; Martig and Mizumori, 2011) and appears to be critically involved in temporal analysis when there are long delays among relevant stimuli (e.g., Hunsaker and Kesner, 2008; Farovik et al., 2010). Because CA1 is involved in temporal analysis in presence of long delays and receives a learning signal from areas that respond phasically to reinforcers such as the ventral tegmental area (VTA), it might serve a function in keeping the reinforcer effective during the 7 s delay in the experiment by Foerde et al. [...]different neural structures have been shown to be sensitive to different timescales (for a review, see Buhusi and Meck, 2005).
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2013.00098