Systematic review on antipruritic therapies for patients with Epidermolysis bullosa

Itch is one of the most burdensome symptoms in epidermolysis bullosa (EB), indicating a hitherto unmet therapeutic need. This review leverages existing data on efficacy of itch treatment in EB to support sound decision making. A systematic literature search was performed on 29 March 2022. Studies wr...

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Bibliographic Details
Published in:The Journal of dermatological treatment 2024-12, Vol.35 (1), p.2381762
Main Authors: Welponer, Tobias, Puttinger, Christian, Korte, Eva W H, van der Werf, Sjoukje, Prodinger, Christine, Bolling, Marieke C, Laimer, Martin
Format: Article
Language:English
Subjects:
Antipruritics - therapeutic use
disease severity
Epidermolysis bullosa
Epidermolysis Bullosa - complications
Epidermolysis Bullosa - therapy
Humans
itch treatment
Pruritus - drug therapy
Pruritus - etiology
quality of life
Skin Care
study outcomes
Treatment Outcome
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Summary:Itch is one of the most burdensome symptoms in epidermolysis bullosa (EB), indicating a hitherto unmet therapeutic need. This review leverages existing data on efficacy of itch treatment in EB to support sound decision making. A systematic literature search was performed on 29 March 2022. Studies written later than 1991 and reporting outcomes in patients with EB treated for itch were considered. Of the 3,099 articles screened, 21 studies met eligibility criteria, comprising 353 patients (65.9%) diagnosed for recessive dystrophic EB. Only two studies (9.5%) evaluated itch as primary endpoint, of which solely one revealed a significant relief of self-reported itch upon topical skin care. In those studies assessing itch as secondary endpoint (19/21, 90.5%), only 36.8% studies (  = 7/19) revealed a statistically significant itch reduction of up to 42%. Methodological limitations (heterogeneity of outcomes, inconsistent data assessment) in addition to limited superiority over control were implicated to account for low treatment efficacy observed in most studies. Current data quality impairs comparative efficacy analyses of itch treatments in EB. Large scale randomized clinical trials and more personalized approaches applying validated measurement instruments for core outcomes are needed to substantiate evidence-based treatment approaches for EB-associated itch.
ISSN:0954-6634
1471-1753
1471-1753
DOI:10.1080/09546634.2024.2381762