Depressive symptoms and dispositional optimism in relation to mortality in older post-myocardial infarction patients

•Cardiovascular disease and depressive symptoms are bidirectional related, were as this for cardiovascular disease and low dispositional optimism is not yet clear.•Older patients with a history of myocardial infarction who scored high on the Geriatric Depression Scale had an increased mortality rate...

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Bibliographic Details
Published in:Journal of affective disorders reports 2021-07, Vol.5, p.100132, Article 100132
Main Authors: Boesten, Renee H.M., Geleijnse, Johanna M., Kromhout, Daan, Ottenheim, Nathaly Rius, Giltay, Erik J.
Format: Article
Language:English
Subjects:
Cardiovascular disease
Depressive symptoms
Dispositional optimism
Mortality
Myocardial infarction
Optimism
Post-myocardial infarction
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Summary:•Cardiovascular disease and depressive symptoms are bidirectional related, were as this for cardiovascular disease and low dispositional optimism is not yet clear.•Older patients with a history of myocardial infarction who scored high on the Geriatric Depression Scale had an increased mortality rate.•Apathy and vitality items were of most influential in relation to the outcome variables.•In the same patient population no association was found between mortality rate and an low score on the Dispositional Optimism Scale (4Q). Mental well-being, characterized by low depressive symptoms and high dispositional optimism, is a protective factor against (cardiovascular) mortality in the general population. We aimed to assess whether such a relationship is also present in patients who have a history of MI, and whether it is independent of classic CVD risk factors. A secondary analysis of the Alpha Omega Trial cohort study was carried out, including 3566 patients with MI in their medical history and a mean follow-up period of 9.0 (SD 2.6) years. The 4Q and GDS were analysed in relation to (cause-specific) mortality using Cox proportionalhazards models adjusted for demographic and classic CVD risk factors. Patients were on average 71.2 years old (SD 5.4), and 20.5% were women. During the follow-up period, there were 1,219 deaths of which 448 (46.7%) as a result of CVD. For the allcause and CVD mortality, the multivariate-adjusted HR for depressive symptoms was 1.85 and 1.90 for the upper tertile versus the lower tertile (95% CI: 1.47–2.33; P for trend
ISSN:2666-9153
2666-9153
DOI:10.1016/j.jadr.2021.100132