Components of particulate matter air-pollution and brain tumors

•A nationwide, register-based, case-control study with 12 928 brain tumor cases.•State of the art air pollution modeling for all addresses 10 years before diagnosis.•Primary emitted carbonaceous particles was associated with malignant brain tumors.•Results need replication. Air pollution is an estab...

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Bibliographic Details
Published in:Environment international 2020-11, Vol.144, p.106046, Article 106046
Main Authors: Harbo Poulsen, Aslak, Arthur Hvidtfeldt, Ulla, Sørensen, Mette, Puett, Robin, Ketzel, Matthias, Brandt, Jørgen, Christensen, Jesper H., Geels, Camilla, Raaschou-Nielsen, Ole
Format: Article
Language:English
Subjects:
Air Pollutants - analysis
Air Pollution - adverse effects
Air Pollution - analysis
Air-pollution
Brain Neoplasms - epidemiology
Brain tumors
Environmental Exposure
Epidemiology
Humans
Particulate matter
Particulate Matter - adverse effects
Particulate Matter - analysis
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Summary:•A nationwide, register-based, case-control study with 12 928 brain tumor cases.•State of the art air pollution modeling for all addresses 10 years before diagnosis.•Primary emitted carbonaceous particles was associated with malignant brain tumors.•Results need replication. Air pollution is an established carcinogen. Evidence for an association with brain tumors is, however, inconclusive. We investigated if individual particulate matter constituents were associated with brain tumor risk. From comprehensive national registers, we identified all (n = 12 928) brain tumor cases, diagnosed in Denmark in the period 1989–2014, and selected 22 961 controls, matched on age, sex and year of birth. We established address histories and estimated 10-year mean residential outdoor concentrations of particulate matter 
ISSN:0160-4120
1873-6750
DOI:10.1016/j.envint.2020.106046