Formulation of silymarin surface modified vesicles: In vitro characterization to cell viability assessment

Silymarin (SLR) is a poorly water-soluble bioactive compound with a wide range of therapeutic activities. Nanosized silymarin vesicles (F1–F6) were prepared by the solvent evaporation rehydration method. The silymarin vesicles were evaluated for vesicle size, surface charge, entrapment efficiency, a...

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Bibliographic Details
Published in:Saudi pharmaceutical journal 2024-06, Vol.32 (6), p.102072-102072, Article 102072
Main Authors: Imam, Syed Sarim, Alshammari, Sultan Owaid, Alshehri, Sultan, Mahdi, Wael A., Al-Agamy, Mohamed H.
Format: Article
Language:English
Subjects:
Antimicrobial
Cell line
Chitosan
Silymarin
Vesicles
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Summary:Silymarin (SLR) is a poorly water-soluble bioactive compound with a wide range of therapeutic activities. Nanosized silymarin vesicles (F1–F6) were prepared by the solvent evaporation rehydration method. The silymarin vesicles were evaluated for vesicle size, surface charge, entrapment efficiency, and drug release studies. The optimized SLR lipid vesicle (F3) was further modified with the addition of the cationic polymer chitosan. After that, the modified vesicle (F3C1) was assessed for permeation flux, antimicrobial activity, cell viability, and molecular docking studies. The silymarin vesicles showed nanometric size (
ISSN:1319-0164
2213-7475
DOI:10.1016/j.jsps.2024.102072