Isolaurenidificin and Bromlaurenidificin, Two New C15-Acetogenins from the Red Alga Laurencia obtusa

Chromatographic fractionation of the CH2Cl2/MeOH extract of the Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C15-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses of their spect...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2017-05, Vol.22 (5), p.807
Main Authors: Bawakid, Nahed, Alarif, Walied, Alburae, Najla, Alorfi, Hajer, Al-Footy, Khalid, Al-Lihaibi, Sultan, Ghandourah, Mohamed
Format: Article
Language:English
Subjects:
Algae
anti-inflammatory
Apoptosis
Artemia
Breast cancer
Chromatography
Cytotoxicity
fatty acids
Fractionation
halogenations
Leukocytes (neutrophilic)
Liver cancer
marine algae
Metabolites
Peripheral blood
Prostate cancer
Spectra
spectroscopy
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chromatographic fractionation of the CH2Cl2/MeOH extract of the Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C15-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses of their spectral data. Compounds 1 and 2 showed no toxicity (LC50 > 12 mM) using Artemia salina as test organism. Both compounds showed weak cytotoxicity against A549, HepG-2, HCT116, MCF-7, and PC-3 cells, however, they exhibited a relatively potent cytotoxic activity against peripheral blood neutrophils. This can be attributed partly to induction of apoptosis.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules22050807